TY - JOUR

T1 - Atomic Layer Deposition of Antibacterial Nanocoatings: A Review

AU - Nazarov, D.

AU - Kozlova, L.

AU - Rogacheva, E.

AU - Kraeva, L.

AU - Maximov, M.

N1 - Export Date: 21 August 2024; Cited By: 3; Correspondence Address: D. Nazarov; Peter the Great Saint Petersburg Polytechnic University, Saint Petersburg, Polytechnicheskaya, 29, 195221, Russian Federation; email: dennazar1@yandex.ru

PY - 2023/11/24

Y1 - 2023/11/24

N2 - In recent years, antibacterial coatings have become an important approach in the global fight against bacterial pathogens. Developments in materials science, chemistry, and biochemistry have led to a plethora of materials and chemical compounds that have the potential to create antibacterial coatings. However, insufficient attention has been paid to the analysis of the techniques and technologies used to apply these coatings. Among the various inorganic coating techniques, atomic layer deposition (ALD) is worthy of note. It enables the successful synthesis of high-purity inorganic nanocoatings on surfaces of complex shape and topography, while also providing precise control over their thickness and composition. ALD has various industrial applications, but its practical application in medicine is still limited. In recent years, a considerable number of papers have been published on the proposed use of thin films and coatings produced via ALD in medicine, notably those with antibacterial properties. The aim of this paper is to carefully evaluate and analyze the relevant literature on this topic. Simple oxide coatings, including TiO2, ZnO, Fe2O3, MgO, and ZrO2, were examined, as well as coatings containing metal nanoparticles such as Ag, Cu, Pt, and Au, and mixed systems such as TiO2-ZnO, TiO2-ZrO2, ZnO-Al2O3, TiO2-Ag, and ZnO-Ag. Through comparative analysis, we have been able to draw conclusions on the effectiveness of various antibacterial coatings of different compositions, including key characteristics such as thickness, morphology, and crystal structure. The use of ALD in the development of antibacterial coatings for various applications was analyzed. Furthermore, assumptions were made about the most promising areas of development. The final section provides a comparison of different coatings, as well as the advantages, disadvantages, and prospects of using ALD for the industrial production of antibacterial coatings. © 2023 by the authors.

AB - In recent years, antibacterial coatings have become an important approach in the global fight against bacterial pathogens. Developments in materials science, chemistry, and biochemistry have led to a plethora of materials and chemical compounds that have the potential to create antibacterial coatings. However, insufficient attention has been paid to the analysis of the techniques and technologies used to apply these coatings. Among the various inorganic coating techniques, atomic layer deposition (ALD) is worthy of note. It enables the successful synthesis of high-purity inorganic nanocoatings on surfaces of complex shape and topography, while also providing precise control over their thickness and composition. ALD has various industrial applications, but its practical application in medicine is still limited. In recent years, a considerable number of papers have been published on the proposed use of thin films and coatings produced via ALD in medicine, notably those with antibacterial properties. The aim of this paper is to carefully evaluate and analyze the relevant literature on this topic. Simple oxide coatings, including TiO2, ZnO, Fe2O3, MgO, and ZrO2, were examined, as well as coatings containing metal nanoparticles such as Ag, Cu, Pt, and Au, and mixed systems such as TiO2-ZnO, TiO2-ZrO2, ZnO-Al2O3, TiO2-Ag, and ZnO-Ag. Through comparative analysis, we have been able to draw conclusions on the effectiveness of various antibacterial coatings of different compositions, including key characteristics such as thickness, morphology, and crystal structure. The use of ALD in the development of antibacterial coatings for various applications was analyzed. Furthermore, assumptions were made about the most promising areas of development. The final section provides a comparison of different coatings, as well as the advantages, disadvantages, and prospects of using ALD for the industrial production of antibacterial coatings. © 2023 by the authors.

KW - antibacterial coatings

KW - atomic layer deposition

KW - medical implants

KW - silver coatings

KW - titanium oxide

KW - zinc oxide

KW - aluminum oxide

KW - chemical compound

KW - iron oxide

KW - magnesium oxide

KW - metal nanoparticle

KW - nanocoating

KW - nanotube

KW - reactive oxygen metabolite

KW - silver nanoparticle

KW - titanium dioxide

KW - water

KW - zirconium oxide

KW - accumulation assay

KW - air

KW - animal cell

KW - antibacterial activity

KW - bacterial growth

KW - bactericidal activity

KW - bacterium adherence

KW - bacterium contamination

KW - biochemistry

KW - biocompatibility

KW - biofilm

KW - biotransformation

KW - bone development

KW - Candida albicans

KW - chemical reaction

KW - chemistry

KW - coating (procedure)

KW - coating uniformity

KW - colony forming unit

KW - coronavirus disease 2019

KW - crystal structure

KW - disinfection

KW - electrospinning

KW - Enterococcus faecalis

KW - Escherichia coli

KW - field emission scanning electron microscopy

KW - Fusobacterium nucleatum

KW - growth rate

KW - materials science

KW - MC3T3-E1 cell line

KW - meta analysis

KW - methicillin resistant Staphylococcus aureus

KW - microscopy

KW - morphology

KW - mouse

KW - nonhuman

KW - pandemic

KW - particle size

KW - photocatalysis

KW - photochemical deposition

KW - photochemistry

KW - Porphyromonas gingivalis

KW - Pseudomonas aeruginosa

KW - purification

KW - Review

KW - scanning electron microscopy

KW - silver accumulation

KW - spray coating

KW - Staphylococcus aureus

KW - surface analysis

KW - synergistic effect

KW - systematic review

KW - thermostability

KW - thickness

KW - topography

KW - transmission electron microscopy

KW - ultraviolet radiation

KW - wettability

KW - X ray photoemission spectroscopy

U2 - 10.3390/antibiotics12121656

DO - 10.3390/antibiotics12121656

M3 - статья

VL - 12

JO - Antibiotics

JF - Antibiotics

SN - 2079-6382

IS - 12

M1 - 1656

ER -