Результаты исследований: Научные публикации в периодических изданиях › статья
Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls. / McLaren, P.J.; Coulonges, C.; Ripke, S.; van den Berg, L.; Buchbinder, S.; Carrington, M.; Cossarizza, A.; Dalmau, J.; Deeks, S.G.; Delaneau, O.; De Luca, A.; Goedert, J.J.; Haas, D.; Herbeck, J.T.; Kathiresan, S.; Kirk, G.D.; Lambotte, O.; Luo, M.; Mallal, S.; van Manen, D.; Martinez-Picado, J.; Meyer, L.; Mullins, J.I.; Obel, N.; O'Brien, S.J.; Pereyra, F.; Plummer, F.A.; Poli, G.; Qi, Y.; Rucart, P.; Sandhu, M.S.; Shea, P.R.; Schuitemaker, H.; Theodorou, I.; Vannberg, F.; Veldink, J.; Walker, B.D.; Weintrob, A.; Winkler, C.A.; Wolinsky, S.; Telenti, A.; Goldstein, D.B.; de Bakker, P.I.W.; Zagury, J.-F.; Fellay, J.
в: PLoS Pathogens, № 7, 2013.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls
AU - McLaren, P.J.
AU - Coulonges, C.
AU - Ripke, S.
AU - van den Berg, L.
AU - Buchbinder, S.
AU - Carrington, M.
AU - Cossarizza, A.
AU - Dalmau, J.
AU - Deeks, S.G.
AU - Delaneau, O.
AU - De Luca, A.
AU - Goedert, J.J.
AU - Haas, D.
AU - Herbeck, J.T.
AU - Kathiresan, S.
AU - Kirk, G.D.
AU - Lambotte, O.
AU - Luo, M.
AU - Mallal, S.
AU - van Manen, D.
AU - Martinez-Picado, J.
AU - Meyer, L.
AU - Mullins, J.I.
AU - Obel, N.
AU - O'Brien, S.J.
AU - Pereyra, F.
AU - Plummer, F.A.
AU - Poli, G.
AU - Qi, Y.
AU - Rucart, P.
AU - Sandhu, M.S.
AU - Shea, P.R.
AU - Schuitemaker, H.
AU - Theodorou, I.
AU - Vannberg, F.
AU - Veldink, J.
AU - Walker, B.D.
AU - Weintrob, A.
AU - Winkler, C.A.
AU - Wolinsky, S.
AU - Telenti, A.
AU - Goldstein, D.B.
AU - de Bakker, P.I.W.
AU - Zagury, J.-F.
AU - Fellay, J.
PY - 2013
Y1 - 2013
N2 - Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is kno
AB - Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is kno
U2 - 10.1371/journal.ppat.1003515
DO - 10.1371/journal.ppat.1003515
M3 - Article
JO - PLoS Pathogens
JF - PLoS Pathogens
SN - 1553-7366
IS - 7
ER -
ID: 7522111