• I. I. Akhmetov
  • D. V. Popov
  • I. A. Mozhaǐskaia
  • S. S. Missina
  • I. V. Astratenkova
  • O. L. Vinogradova
  • V. A. Rogozkin

The aim of study was to investigate an allelic distribution of PPARA (G/C polymorphism), PPARG (Pro/Ala), PPARD (+294T/C) and PGCIA (Gly482Ser) genes in rowers (n=205) and controls (n=659), and to find correlation between genotypes and physiological parameters. Genotyping was performed by restriction fragment length polymorphism analysis. Physiological parameters were evaluated by PM 3 Rower Ergometer and MetaMax 3B Gas Analyzer. The frequencies ofPPARA G (90.1% vs. 83.6%) and PPARG Ala (23.1% vs. 16.2%) alleles in elite athletes, and of PPARD C (19.1% vs. 10.5%) and PGC1A Gly (75.4% vs. 66.5%) alleles in sub-elite athletes were significantly higher than in controls. Moreover, PPARA G (when oxygen pulse was measured) and PGC 1A Gly (when maximal aerobic power and anaerobic threshold (%) of VO2max were measured) alleles were associated with high values of aerobic performance. Thus, PPARA G, PPARG Ala, PPARD C and PGCIA Gly alleles can be considered as genetic markers associated with enhanced physical performance.

Язык оригиналаанглийский
Страницы (с-по)837-843
Число страниц7
ЖурналRossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk
Том93
Номер выпуска8
СостояниеОпубликовано - 1 авг 2007

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