Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. / Zhebrun, Daria; Kudryashova, Yulia; Babenko, Alina; Maslyansky, Alexei; Kunitskaya, Natalya; Popcova, Daria; Klushina, Alexandra; Grineva, Elena; Kostareva, Anna; Shlyakhto, Evgeny.
в: Aging, Том 3, № 4, 04.2011, стр. 368-373.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population
AU - Zhebrun, Daria
AU - Kudryashova, Yulia
AU - Babenko, Alina
AU - Maslyansky, Alexei
AU - Kunitskaya, Natalya
AU - Popcova, Daria
AU - Klushina, Alexandra
AU - Grineva, Elena
AU - Kostareva, Anna
AU - Shlyakhto, Evgeny
PY - 2011/4
Y1 - 2011/4
N2 - The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors (TCR). Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D). The aim of this study was to analyze a possible association between 1858 C/T SNP and a number of autoimmune diseases, including RA, GD and T1D in Russian population. Patients with T1D, GD, RA and healthy controls were genotyped for the 1858 C/T SNP in PTPN22 gene. We found a significant association between PTPN22 1858 C/T SNP and T1D and GD. 1858T/T genotype was observed more frequently in T1D and GD patients compared to control subjects. No such association was observed for RA. In concordance with a previous data establishing PTPN22 1858 C/T SNP association with several autoimmune diseases, our findings provide further evidence that the PTPN22 gene may play an important role in the susceptibility to some autoimmune diseases.
AB - The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors (TCR). Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D). The aim of this study was to analyze a possible association between 1858 C/T SNP and a number of autoimmune diseases, including RA, GD and T1D in Russian population. Patients with T1D, GD, RA and healthy controls were genotyped for the 1858 C/T SNP in PTPN22 gene. We found a significant association between PTPN22 1858 C/T SNP and T1D and GD. 1858T/T genotype was observed more frequently in T1D and GD patients compared to control subjects. No such association was observed for RA. In concordance with a previous data establishing PTPN22 1858 C/T SNP association with several autoimmune diseases, our findings provide further evidence that the PTPN22 gene may play an important role in the susceptibility to some autoimmune diseases.
KW - Graves' disease
KW - Protein tyrosine phosphatase nonreceptor 22
KW - Rheumatoid arthritis
KW - Singlenucleotide polymorphism
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=80052098376&partnerID=8YFLogxK
U2 - 10.18632/aging.100305
DO - 10.18632/aging.100305
M3 - Article
C2 - 21467606
AN - SCOPUS:80052098376
VL - 3
SP - 368
EP - 373
JO - Aging
JF - Aging
SN - 1945-4589
IS - 4
ER -
ID: 93112463