TY - JOUR

T1 - Association of apoprotein A-1 genetic variants with development of atherosclerosis in the population of St. Petersburg

AU - Miroshnikova, V. V.

AU - Rodygina, T. I.

AU - Demina, E. P.

AU - Kurjanov, P. S.

AU - Urazgildeeva, S. A.

AU - Gurevich, V. S.

AU - Schwarzman, A. L.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Apoprotein A-1 is the major protein of antiatherogenic high density lipoproteins and one of the key proteins regulating reverse cholesterol transport. The goal of this work was to study the association of the APOA1 gene polymorphism with development of atherosclerosis in the population of St. Petersburg. Allelic frequencies of polymorphic variants (-75)G/A and 83C/T of the APOA1 gene were determined in a group of patients with angiographically proven atherosclerosis and in the control group. Allele 83T of the APOA1 gene was associated with a lower risk of developing atherosclerosis in residents of St. Petersburg.

AB - Apoprotein A-1 is the major protein of antiatherogenic high density lipoproteins and one of the key proteins regulating reverse cholesterol transport. The goal of this work was to study the association of the APOA1 gene polymorphism with development of atherosclerosis in the population of St. Petersburg. Allelic frequencies of polymorphic variants (-75)G/A and 83C/T of the APOA1 gene were determined in a group of patients with angiographically proven atherosclerosis and in the control group. Allele 83T of the APOA1 gene was associated with a lower risk of developing atherosclerosis in residents of St. Petersburg.

KW - APOA1 gene

KW - apoprotein A1

KW - atherosclerosis

KW - reverse cholesterol transport

UR - http://www.scopus.com/inward/record.url?scp=84864750365&partnerID=8YFLogxK

U2 - 10.1134/S207905971105011X

DO - 10.1134/S207905971105011X

M3 - Article

VL - 1

SP - 411

EP - 415

JO - Russian Journal of Genetics: Applied Research

JF - Russian Journal of Genetics: Applied Research

SN - 2079-0597

IS - 5

ER -