We carried out a study of action of helium-neon laser irradiation on the course of the wound process. For this purpose we used helium-neon optic quantum generator with the emission wavelength of 0.6328 μm. The cytological study has shown that the laser irradiation activates processes of phagocytosis and reparation and reduces microbial insemination of wounds. The histological, histochemical, and electron microscopic studies of the dynamics of gun wound healing have shown that under effect of laser irradiation, duration of the inflammatory reaction and the associated incidence of infectious complications were reduced; the initial signs of cell proliferation appeared sooner. Further, acceleration of differentiation of fibroblasts and an increase of their collagen-synthetic activity were noticed.