TY - JOUR

T1 - ANALYSIS OF THE LEVEL OF B-CELL POPULATIONS IN PATIENTS WITH PULMONARY SARCOIDOSIS

AU - Malkova, A. M.

AU - Kudryavtsev, I. V.

AU - Basantsova, N. Yu.

AU - Zinchenko, Yu. S.

AU - Starshinova, A. A.

AU - Churilov, L. P.

AU - Yablonskiy, P. K.

N1 - Malkova A. M., Kudryavtsev I. V., Basantsova N. Yu., Zinchenko Yu. S., Starshinova A. A., Churilov L. P., Yablonskiy P. K. Analysis of the level of B-cell populations in patients with pulmo-nary sarcoidosis. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 4, pp. 322–324

PY - 2019

Y1 - 2019

N2 - Sarcoidosis is a granulomatous disease of unknown etiology. The role of B-cells in pathogene-sis of sarcoidosis was shown in several studies. The importance of B-lymphocytes activation in sarcoidosis can be confirmed by the efficacy of anti-CD20 treatment. However, there is no data about alteration of certain B-cells subsets. In this study changes in subsets of B-lymphocytes in patients with sarcoidosis (n = 37) and a control group (n = 30) are analyzed. In patients with sarcoidosis misbalance of B-naïve and B-memory cells was found, the level of B-naïve cells proved to be more than 70.00 % and B memory cells less than 30.00 % (sensitivity 76 %, speci-ficity 70 %). Among regulatory B cells there was detected an elevation of CD24+++CD38+++ B cells more than 6.5 % (sensitivity 91 %, specificity 88 %) and CD5+CD27-B cells than 12.45 % (sensitivity 76 %, specificity 80 %). These results show, that in sarcoidosis pathogenesis are in-volved B-naïve and B-memory cells, that is characteristic for granulomatous diseases, and also regulatory B cells, that produce anti-inflammatory cytokines.

AB - Sarcoidosis is a granulomatous disease of unknown etiology. The role of B-cells in pathogene-sis of sarcoidosis was shown in several studies. The importance of B-lymphocytes activation in sarcoidosis can be confirmed by the efficacy of anti-CD20 treatment. However, there is no data about alteration of certain B-cells subsets. In this study changes in subsets of B-lymphocytes in patients with sarcoidosis (n = 37) and a control group (n = 30) are analyzed. In patients with sarcoidosis misbalance of B-naïve and B-memory cells was found, the level of B-naïve cells proved to be more than 70.00 % and B memory cells less than 30.00 % (sensitivity 76 %, speci-ficity 70 %). Among regulatory B cells there was detected an elevation of CD24+++CD38+++ B cells more than 6.5 % (sensitivity 91 %, specificity 88 %) and CD5+CD27-B cells than 12.45 % (sensitivity 76 %, specificity 80 %). These results show, that in sarcoidosis pathogenesis are in-volved B-naïve and B-memory cells, that is characteristic for granulomatous diseases, and also regulatory B cells, that produce anti-inflammatory cytokines.

U2 - 0.21638/spbu11.2019.416

DO - 0.21638/spbu11.2019.416

M3 - Article

VL - 14

SP - 322

EP - 324

JO - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

JF - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

SN - 1818-2909

IS - 4

Y2 - 11 October 2019 through 13 October 2019

ER -