TY - JOUR

T1 - An efficient synthesis and antimicrobial evaluation of 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles

AU - Tarasenko, Marina

AU - Sidneva, Vera

AU - Belova, Alexandra

AU - Romanycheva, Anna

AU - Шаронова, Татьяна Валерьевна

AU - Байков, Сергей Валентинович

AU - Shetnev, Anton

AU - Kofanov, Eugeniy

AU - Кузнецов, Михаил Анатольевич

N1 - M. Tarasenko, V. Sidneva, A. Belova, A. Romanycheva, T. Sharonova, S. Baykov, A. Shetnev, E. Kofanov, М.А. Кuznetsov. An efficient synthesis and antimicrobial evaluation of 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles. Arkivoc, 2018, part vii, 458-470. DOI: https://doi.org/10.24820/ark.5550190.p010.760. IF 1.048

PY - 2018/12

Y1 - 2018/12

N2 - The cyclodehydration of O-acylamidoximes at room temperature in the superbase system KOH/DMSOrepresents a simple and efficient way to 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles. This method is suitable forthe preparation of 5-(4-vinylphenyl)-1,2,4-oxadiazoles as well. Results of the antimicrobial tests demonstratedthat the synthesized compounds exhibit a moderate antimicrobial effect against E.coli, S.aureus and C.albicansstrains.

AB - The cyclodehydration of O-acylamidoximes at room temperature in the superbase system KOH/DMSOrepresents a simple and efficient way to 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles. This method is suitable forthe preparation of 5-(4-vinylphenyl)-1,2,4-oxadiazoles as well. Results of the antimicrobial tests demonstratedthat the synthesized compounds exhibit a moderate antimicrobial effect against E.coli, S.aureus and C.albicansstrains.

KW - Heterocycles, O-acylamidoximes, cyclodehydration, base catalysis, antimicrobial activity

M3 - Article

VL - 2018

SP - 458

EP - 470

JO - Arkivoc

JF - Arkivoc

SN - 1551-7004

IS - 7

ER -