An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D2 Receptor Ligands

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An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D₂Receptor Ligands. / Grintsevich, Sergey ; Sapegin, Alexander; Duszyńska, Beata; Bojarski, Andrzej J.; Krasavin, Mikhail.

в: Synthesis (Germany), Том 54, № 3, 27.10.2021, стр. 658-666.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{51693124825a4adea0e5496a337513fa,

title = "An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D2 Receptor Ligands",

abstract = "Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) did not result in ring expansion but, rather, led to 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2ligands with elements of structureactivity relationships.",

keywords = "2-aminoethyl side chain expulsion, fused imidazolinium moiety, hydrated imidazoline ring expansion, selective dopamine D ligands, [1,4]diazepinones, selective dopamine D-2 ligands",

author = "Sergey Grintsevich and Alexander Sapegin and Beata Duszy{\'n}ska and Bojarski, {Andrzej J.} and Mikhail Krasavin",

year = "2021",

month = oct,

day = "27",

doi = "10.1055/a-1649-5317",

language = "English",

volume = "54",

pages = "658--666",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "3",

}

RIS

TY - JOUR

T1 - An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D2 Receptor Ligands

AU - Grintsevich, Sergey

AU - Sapegin, Alexander

AU - Duszyńska, Beata

AU - Bojarski, Andrzej J.

AU - Krasavin, Mikhail

PY - 2021/10/27

Y1 - 2021/10/27

N2 - Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) did not result in ring expansion but, rather, led to 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2ligands with elements of structureactivity relationships.

AB - Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) did not result in ring expansion but, rather, led to 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2ligands with elements of structureactivity relationships.

KW - 2-aminoethyl side chain expulsion

KW - fused imidazolinium moiety

KW - hydrated imidazoline ring expansion

KW - selective dopamine D ligands

KW - [1,4]diazepinones

KW - selective dopamine D-2 ligands

UR - http://www.scopus.com/inward/record.url?scp=85118672826&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/b153a452-51d5-38cc-8d57-4c9704c9e735/

U2 - 10.1055/a-1649-5317

DO - 10.1055/a-1649-5317

M3 - Article

AN - SCOPUS:85118672826

VL - 54

SP - 658

EP - 666

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 3

ER -

ID: 88430951