Alpha-enolase involvement in intestinal and extraintestinal manifestations of celiac disease

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Alpha-enolase involvement in intestinal and extraintestinal manifestations of celiac disease. / Lerner, Aaron; Sobolevskaia, Polina ; Churilov, Leonid ; Shoenfeld, Yehuda.

в: Journal of Translational Autoimmunity, Том 4, 100109, 06.2021.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{e2d9cc1a3c744d9fb4f7d31f2fa9a03a,

title = "Alpha-enolase involvement in intestinal and extraintestinal manifestations of celiac disease",

abstract = "Celiac disease is a life-long intestinal autoimmune disease, characterized by the gluten intolerance and chronic enteric inflammation. Traditionally presented by intestinal manifestations, however, a shift toward extra intestinal presentation is taking place. One of the affected organs is the nervous systems presented by neuropsychiatric manifestations, hence the mechanism and pathways are not clear. The presence of neuronal and alpha-enolases and their corresponding antibodies were noticed in the mucosa and serum of celiac disease patients, as well as in other various autoimmune diseases with psycho-neurological manifestations. The aims of the present review are to screen the literature on different isoforms of enolase, mainly alpha enolase, and their specific antibodies and to suggest their potential pathophysiological mechanisms relaying the enolases to intestinal or extraintestinal celiac disease manifestations. The shared aspects between the enolases and celiac disease and the cross-talks between alpha-enolase and tissue transglutaminase suggest new potential pathophysiological mechanisms that might drive celiac disease evolvement.",

keywords = "Anti-alpha-enolase, Autoimmune disease, Celiac disease, Extraintestinal manifestation, Gluten, Neuron-specific enolase, CARCINOID-TUMOR, ANTIBODIES, AUTOANTIBODIES, PROTEIN, CROHNS-DISEASE, TRANSGLUTAMINASE, SMALL-BOWEL, CEREBROSPINAL-FLUID, IDENTIFICATION, NEURON-SPECIFIC ENOLASE",

author = "Aaron Lerner and Polina Sobolevskaia and Leonid Churilov and Yehuda Shoenfeld",

year = "2021",

month = jun,

doi = "10.1016/j.jtauto.2021.100109",

language = "English",

volume = "4",

journal = "Journal of Translational Autoimmunity",

issn = "2589-9090",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Alpha-enolase involvement in intestinal and extraintestinal manifestations of celiac disease

AU - Lerner, Aaron

AU - Sobolevskaia, Polina

AU - Churilov, Leonid

AU - Shoenfeld, Yehuda

PY - 2021/6

Y1 - 2021/6

N2 - Celiac disease is a life-long intestinal autoimmune disease, characterized by the gluten intolerance and chronic enteric inflammation. Traditionally presented by intestinal manifestations, however, a shift toward extra intestinal presentation is taking place. One of the affected organs is the nervous systems presented by neuropsychiatric manifestations, hence the mechanism and pathways are not clear. The presence of neuronal and alpha-enolases and their corresponding antibodies were noticed in the mucosa and serum of celiac disease patients, as well as in other various autoimmune diseases with psycho-neurological manifestations. The aims of the present review are to screen the literature on different isoforms of enolase, mainly alpha enolase, and their specific antibodies and to suggest their potential pathophysiological mechanisms relaying the enolases to intestinal or extraintestinal celiac disease manifestations. The shared aspects between the enolases and celiac disease and the cross-talks between alpha-enolase and tissue transglutaminase suggest new potential pathophysiological mechanisms that might drive celiac disease evolvement.

AB - Celiac disease is a life-long intestinal autoimmune disease, characterized by the gluten intolerance and chronic enteric inflammation. Traditionally presented by intestinal manifestations, however, a shift toward extra intestinal presentation is taking place. One of the affected organs is the nervous systems presented by neuropsychiatric manifestations, hence the mechanism and pathways are not clear. The presence of neuronal and alpha-enolases and their corresponding antibodies were noticed in the mucosa and serum of celiac disease patients, as well as in other various autoimmune diseases with psycho-neurological manifestations. The aims of the present review are to screen the literature on different isoforms of enolase, mainly alpha enolase, and their specific antibodies and to suggest their potential pathophysiological mechanisms relaying the enolases to intestinal or extraintestinal celiac disease manifestations. The shared aspects between the enolases and celiac disease and the cross-talks between alpha-enolase and tissue transglutaminase suggest new potential pathophysiological mechanisms that might drive celiac disease evolvement.

KW - Anti-alpha-enolase

KW - Autoimmune disease

KW - Celiac disease

KW - Extraintestinal manifestation

KW - Gluten

KW - Neuron-specific enolase

KW - CARCINOID-TUMOR

KW - ANTIBODIES

KW - AUTOANTIBODIES

KW - PROTEIN

KW - CROHNS-DISEASE

KW - TRANSGLUTAMINASE

KW - SMALL-BOWEL

KW - CEREBROSPINAL-FLUID

KW - IDENTIFICATION

KW - NEURON-SPECIFIC ENOLASE

UR - http://www.scopus.com/inward/record.url?scp=85107983118&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d8dced58-a2a8-301b-8240-c7889a16f5e2/

U2 - 10.1016/j.jtauto.2021.100109

DO - 10.1016/j.jtauto.2021.100109

M3 - Article

C2 - 34189450

AN - SCOPUS:85107983118

VL - 4

JO - Journal of Translational Autoimmunity

JF - Journal of Translational Autoimmunity

SN - 2589-9090

M1 - 100109

ER -

ID: 78086694