Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Aldazines were employed in the Castagnoli-Cushman reaction of homophthalic anhydride for the first time. The reaction proved to be distinctly diastereoselective when conducted at room temperature in acetonitrile, yielding predominantly the kinetic cis -configured adduct as a racemate. Thermodynamically more stable trans -configuration could be attained either via heating the cis -configured product in DMSO or via the action of a base (imidazole) in the course of CDI-promoted esterification or amidation of the carboxylic acid function in the initial adducts. Further manipulation of the remaining N -acylhydrazone moiety in the latter led to N -alkyl- or fully unprotected N -aminolactams.
Язык оригинала | английский |
---|---|
Страницы (с-по) | 2076-2086 |
Число страниц | 11 |
Журнал | Synthesis (Germany) |
Том | 50 |
Номер выпуска | 10 |
DOI | |
Состояние | Опубликовано - 17 мая 2018 |
ID: 34633436