TY - JOUR

T1 - Age and serum amh and fsh levels as predictors of the number of oocytes retrieved from chromosomal translocation carriers after controlled ovarian hyperstimulation

T2 - Applicability and limitations

AU - Shilenkova, Yulia V.

AU - Pendina, Anna A.

AU - Mekina, Irina D.

AU - Efimova, Olga A.

AU - Komarova, Evgeniia M.

AU - Lesik, Elena A.

AU - Ishchuk, Mariia A.

AU - Fedorova, Elena M.

AU - Chiryaeva, Olga G.

AU - Petrova, Lubov’ I.

AU - Dudkina, Vera S.

AU - Talantova, Olga E.

AU - Gzgzyan, Alexander M.

AU - Kogan, Igor Yu

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus–oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstim-ulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman’s age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian transloca-tion carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translo-cation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.

AB - We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus–oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstim-ulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation. The number of COCs correlated negatively with the woman’s age in both the reciprocal and the Robertsonian translocation carriers, while in 46,XX women no correlation was detected. The number of COCs did not differ between the reciprocal and the Robertsonian translocation carriers aged either <35 or ≥35 years. In translocation carriers, the number of COCs correlated with the serum AMH level only in the younger-age subgroups; the correlation was strong positive in reciprocal and moderate positive in Robertsonian transloca-tion carriers. The 46,XX women aged both <35 and ≥35 years showed similar moderate positive correlations. Across all subgroups, the number of COCs correlated moderately negatively with the serum FSH level only in Robertsonian translocation carriers aged <35 years. Our results suggest that chromosomal translocations per se do not increase the risk of poor oocyte retrieval outcome after COH. In translocation carriers, oocyte retrieval outcome depends to a large extent on their age. The serum AMH level strongly predicts oocyte retrieval outcomes only in young reciprocal translo-cation carriers, while the serum FSH level has a moderate predictive value in young Robertsonian translocation carriers.

KW - Anti-Müllerian hormone (AMH)

KW - Female age

KW - Follicle-stimulating hormone (FSH)

KW - IVF

KW - Oocyte retrieval

KW - PGT-SR

KW - Translocation carriers

KW - Infertility, Female/blood

KW - Translocation, Genetic

KW - Age Factors

KW - Follicle Stimulating Hormone/blood

KW - Humans

KW - Oocyte Retrieval/statistics & numerical data

KW - Treatment Outcome

KW - Ovulation Induction/statistics & numerical data

KW - Adult

KW - Female

KW - Heterozygote

KW - Retrospective Studies

KW - Anti-Mullerian Hormone/blood

KW - oocyte retrieval

KW - anti-M&#252

KW - llerian hormone (AMH)

KW - female age

KW - follicle-stimulating hormone (FSH)

KW - translocation carriers

UR - http://www.scopus.com/inward/record.url?scp=85098782698&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/f88c19fb-c895-37ef-9edd-5fc4aa9f7b5c/

U2 - 10.3390/genes12010018

DO - 10.3390/genes12010018

M3 - Article

C2 - 33375549

AN - SCOPUS:85098782698

VL - 12

SP - 1

EP - 18

JO - Genes

JF - Genes

SN - 2073-4425

IS - 1

M1 - 18

ER -