TY - JOUR

T1 - Advanced strain elastography is a reliable approach for prostate cancer detection in patients with elevated PSA levels

AU - Almalki, Y.E.

AU - Mansour, M.G.E.-D.

AU - Ali, S.A.

AU - Basha, M.A.A.

AU - Abdelkawi, M.M.

AU - Alduraibi, S.K.

AU - Almushayti, Z.A.

AU - Aldhilan, A.S.

AU - Aboualkheir, M.

AU - Amin, D.

AU - Metkees, M.

AU - Basha, A.M.A.

AU - Ebaid, N.Y.

N1 - Цитирования:1 Export Date: 19 October 2024 Адрес для корреспонденции: Basha, M.A.A.; Department of Radiology, Egypt; эл. почта: Mohammad_basha76@yahoo.com Химические вещества/CAS: Prostate-Specific Antigen Сведения о финансировании: Najran University, NU, NU/NRP/MRC/12/39 Сведения о финансировании: Najran University, NU Текст о финансировании 1: The authors are thankful to the Deanship of Scientific Research at Najran University for funding this work under the General Research funding program (Grant code: NU/NRP/MRC/12/39).

PY - 2024/12/1

Y1 - 2024/12/1

N2 - This study aimed to examine the validity and reproducibility of strain elastography (SE) for detecting prostate cancer (PCa) in patients with elevated prostate-specific antigen (PSA) levels. The study included 107 patients with elevated PSA levels. All eligible patients underwent transrectal ultrasound (TRUS) with real-time elastography (RTE) to detect suspicious lesions. Two readers independently evaluated the lesions and assigned a strain ratio and elastography score to each lesion. Histopathology was used as a reference standard to estimate the validity of RTE in predicting malignant lesions. An intraclass correlation (ICC) was performed to detect reliability of the strain ratios and elastography scores. TRUS-guided biopsy detected malignancies in 64 (59.8%) patients. TRUS with RTE revealed 122 lesions. The strain ratio index (SRI) cut-off values to diagnose malignancy were 4.05 and 4.35, with sensitivity, specificity, and accuracy of 94.7%, 91.3%, and 93.4%, respectively. An elastography score > 3 was the best cut-off value for detecting malignancy. According to readers, the sensitivity, specificity, and accuracy were 91.3–94.7%, 89.5–93.4%, and 91.3–90.9%, respectively. Excellent inter-reader agreement was recorded for SRI and elastography scores, with ICC of 0.937 and 0.800, respectively. SE proves to be an efficient tool for detecting PCa with high accuracy in patients with elevated PSA levels. © The Author(s) 2024.

AB - This study aimed to examine the validity and reproducibility of strain elastography (SE) for detecting prostate cancer (PCa) in patients with elevated prostate-specific antigen (PSA) levels. The study included 107 patients with elevated PSA levels. All eligible patients underwent transrectal ultrasound (TRUS) with real-time elastography (RTE) to detect suspicious lesions. Two readers independently evaluated the lesions and assigned a strain ratio and elastography score to each lesion. Histopathology was used as a reference standard to estimate the validity of RTE in predicting malignant lesions. An intraclass correlation (ICC) was performed to detect reliability of the strain ratios and elastography scores. TRUS-guided biopsy detected malignancies in 64 (59.8%) patients. TRUS with RTE revealed 122 lesions. The strain ratio index (SRI) cut-off values to diagnose malignancy were 4.05 and 4.35, with sensitivity, specificity, and accuracy of 94.7%, 91.3%, and 93.4%, respectively. An elastography score > 3 was the best cut-off value for detecting malignancy. According to readers, the sensitivity, specificity, and accuracy were 91.3–94.7%, 89.5–93.4%, and 91.3–90.9%, respectively. Excellent inter-reader agreement was recorded for SRI and elastography scores, with ICC of 0.937 and 0.800, respectively. SE proves to be an efficient tool for detecting PCa with high accuracy in patients with elevated PSA levels. © The Author(s) 2024.

KW - prostate specific antigen

KW - diagnostic imaging

KW - elastography

KW - human

KW - male

KW - pathology

KW - prostate

KW - prostate tumor

KW - reproducibility

KW - sensitivity and specificity

KW - Elasticity Imaging Techniques

KW - Humans

KW - Male

KW - Prostate

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Prostate/diagnostic imaging

KW - Prostatic Neoplasms/diagnostic imaging

UR - https://www.mendeley.com/catalogue/5b4d6090-a3c6-3551-8db8-f916a9ed7e9e/

U2 - 10.1038/s41598-024-53440-2

DO - 10.1038/s41598-024-53440-2

M3 - статья

C2 - 38316992

VL - 14

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2917

ER -