A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals

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A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals. / Antsiferova, A. A.; Kormazeva, E. S.; Demin, V. F.; Kashkarov, P. K.; Koval’chuk, M. V.

в: Nanotechnologies in Russia, Том 13, № 1-2, 01.01.2018, стр. 51-60.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{89778fb420fd442ab524258e72ec80d0,

title = "A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals",

abstract = "A radiotracer technique is developed using titanium dioxide nanoparticles labeled by fast protons with the acquisition of a 48V radioactive isotope, and the biokinetics of these brookite nanoparticles in the organisms of laboratory rats within the one-time intragastrical injection are studied. The main result of this work is the detection of titanium dioxide in the colon even within 5 days after injecting the slurry in an amount of 0.4% from the total exposition dose, which evidences the accumulation of titanium dioxide nanoparticles in the organ. This means that macro- and nano-fractions of titanium dioxide particles can be potentially dangerous for the colon, exerting a toxic and carcinogenic influence on its epithelial cells. Moreover, some traces of titanium dioxide nanoparticles are found to penetrate into the blood and liver. However, 98% of titanium dioxide is eliminated from the organism with feces within 5 days after injection. Neither kidneys nor brain exhibit the presence of titanium dioxide residues. This effect is due to the agglomeration of titanium dioxide nanoparticles, which is already significant and prompt in the solution for injection. At the same time, despite the ability of agglomerates to dissociate in the acidic medium of the stomach, only a few amounts of titanium dioxide pass into a nanometric form, which then penetrates through the colon into blood.",

author = "Antsiferova, {A. A.} and Kormazeva, {E. S.} and Demin, {V. F.} and Kashkarov, {P. K.} and Koval{\textquoteright}chuk, {M. V.}",

note = "Publisher Copyright: {\textcopyright} 2018, Pleiades Publishing, Ltd.",

year = "2018",

month = jan,

day = "1",

doi = "10.1134/S1995078018010020",

language = "English",

volume = "13",

pages = "51--60",

journal = "Nanobiotechnology Reports",

issn = "2635-1676",

publisher = "Pleiades Publishing",

number = "1-2",

}

RIS

TY - JOUR

T1 - A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals

AU - Antsiferova, A. A.

AU - Kormazeva, E. S.

AU - Demin, V. F.

AU - Kashkarov, P. K.

AU - Koval’chuk, M. V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A radiotracer technique is developed using titanium dioxide nanoparticles labeled by fast protons with the acquisition of a 48V radioactive isotope, and the biokinetics of these brookite nanoparticles in the organisms of laboratory rats within the one-time intragastrical injection are studied. The main result of this work is the detection of titanium dioxide in the colon even within 5 days after injecting the slurry in an amount of 0.4% from the total exposition dose, which evidences the accumulation of titanium dioxide nanoparticles in the organ. This means that macro- and nano-fractions of titanium dioxide particles can be potentially dangerous for the colon, exerting a toxic and carcinogenic influence on its epithelial cells. Moreover, some traces of titanium dioxide nanoparticles are found to penetrate into the blood and liver. However, 98% of titanium dioxide is eliminated from the organism with feces within 5 days after injection. Neither kidneys nor brain exhibit the presence of titanium dioxide residues. This effect is due to the agglomeration of titanium dioxide nanoparticles, which is already significant and prompt in the solution for injection. At the same time, despite the ability of agglomerates to dissociate in the acidic medium of the stomach, only a few amounts of titanium dioxide pass into a nanometric form, which then penetrates through the colon into blood.

AB - A radiotracer technique is developed using titanium dioxide nanoparticles labeled by fast protons with the acquisition of a 48V radioactive isotope, and the biokinetics of these brookite nanoparticles in the organisms of laboratory rats within the one-time intragastrical injection are studied. The main result of this work is the detection of titanium dioxide in the colon even within 5 days after injecting the slurry in an amount of 0.4% from the total exposition dose, which evidences the accumulation of titanium dioxide nanoparticles in the organ. This means that macro- and nano-fractions of titanium dioxide particles can be potentially dangerous for the colon, exerting a toxic and carcinogenic influence on its epithelial cells. Moreover, some traces of titanium dioxide nanoparticles are found to penetrate into the blood and liver. However, 98% of titanium dioxide is eliminated from the organism with feces within 5 days after injection. Neither kidneys nor brain exhibit the presence of titanium dioxide residues. This effect is due to the agglomeration of titanium dioxide nanoparticles, which is already significant and prompt in the solution for injection. At the same time, despite the ability of agglomerates to dissociate in the acidic medium of the stomach, only a few amounts of titanium dioxide pass into a nanometric form, which then penetrates through the colon into blood.

UR - http://www.scopus.com/inward/record.url?scp=85052084587&partnerID=8YFLogxK

U2 - 10.1134/S1995078018010020

DO - 10.1134/S1995078018010020

M3 - Article

AN - SCOPUS:85052084587

VL - 13

SP - 51

EP - 60

JO - Nanobiotechnology Reports

JF - Nanobiotechnology Reports

SN - 2635-1676

IS - 1-2

ER -

ID: 88199767