Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline. / Bakulina, Olga; Ivanov, Alexander; Suslonov, Vitalii; Darin, Dmitry; Krasavin, Mikhail.
в: Beilstein Journal of Organic Chemistry, Том 13, 18.07.2017, стр. 1413-1424.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline
AU - Bakulina, Olga
AU - Ivanov, Alexander
AU - Suslonov, Vitalii
AU - Darin, Dmitry
AU - Krasavin, Mikhail
PY - 2017/7/18
Y1 - 2017/7/18
N2 - A series of 15 benzene-fused hexahydropyrrolo[1,2-b]isoquinolonic acids with substantial degree of steric encumbrance has been prepared via a novel variant of the Castagnoli-Cushman reaction of homophthalic anhydride (HPA) and various indolenines. The employment of a special kind of a cyclic imine component reaction allowed, for the first time, isolating a Mannich-type adduct between HPA and an imine component which has been postulated but never obtained in similar reactions.
AB - A series of 15 benzene-fused hexahydropyrrolo[1,2-b]isoquinolonic acids with substantial degree of steric encumbrance has been prepared via a novel variant of the Castagnoli-Cushman reaction of homophthalic anhydride (HPA) and various indolenines. The employment of a special kind of a cyclic imine component reaction allowed, for the first time, isolating a Mannich-type adduct between HPA and an imine component which has been postulated but never obtained in similar reactions.
KW - Castagnoli-Cushman reaction
KW - Diastereoselectivity
KW - Homophthalic anhydride
KW - Indolenines
KW - Lactam synthesis
KW - Multicomponent reactions
UR - http://www.scopus.com/inward/record.url?scp=85025585812&partnerID=8YFLogxK
U2 - 10.3762/bjoc.13.138
DO - 10.3762/bjoc.13.138
M3 - Article
AN - SCOPUS:85025585812
VL - 13
SP - 1413
EP - 1424
JO - Beilstein Journal of Organic Chemistry
JF - Beilstein Journal of Organic Chemistry
SN - 2195-951X
ER -
ID: 34635463