TY - JOUR

T1 - A pericyte origin of spinal cord scar tissue

AU - Göritz, Christian

AU - Dias, David O.

AU - Tomilin, Nikolay

AU - Barbacid, Mariano

AU - Shupliakov, Oleg

AU - Frisén, Jonas

PY - 2011/7/8

Y1 - 2011/7/8

N2 - There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.

AB - There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=79960099283&partnerID=8YFLogxK

U2 - 10.1126/science.1203165

DO - 10.1126/science.1203165

M3 - Article

C2 - 21737741

AN - SCOPUS:79960099283

VL - 333

SP - 238

EP - 242

JO - Science

JF - Science

SN - 0036-8075

IS - 6039

ER -