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A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives. / Gecht, Martha; Kantin, Grigory; Dar'in, Dmitry; Krasavin, Mikhail.

в: Tetrahedron Letters, Том 60, № 44, 151120, 31.10.2019.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Gecht, M, Kantin, G, Dar'in, D & Krasavin, M 2019, 'A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives', Tetrahedron Letters, Том. 60, № 44, 151120. https://doi.org/10.1016/j.tetlet.2019.151120

APA

Gecht, M., Kantin, G., Dar'in, D., & Krasavin, M. (2019). A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives. Tetrahedron Letters, 60(44), [151120]. https://doi.org/10.1016/j.tetlet.2019.151120

Vancouver

Gecht M, Kantin G, Dar'in D, Krasavin M. A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives. Tetrahedron Letters. 2019 Окт. 31;60(44). 151120. https://doi.org/10.1016/j.tetlet.2019.151120

Author

Gecht, Martha ; Kantin, Grigory ; Dar'in, Dmitry ; Krasavin, Mikhail. / A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives. в: Tetrahedron Letters. 2019 ; Том 60, № 44.

BibTeX

@article{9e9ec1af56004f4b98c00cd495e31fed,
title = "A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives",
abstract = "An alternative route from 1,3-disubstituted barbituric acids to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones was developed that features sulfonyl-azide-free (SAFE) diazo transfer and Rh2(esp)2-catalyzed cycloaddition of the resulting 5-diazobarbituric acids with aliphatic and aromatic nitriles. Besides being shorter compared to the previously described approaches, the method allows introduction of alkyl substituents at the 1,3-oxazole ring of the fused heterocyclic system.",
keywords = "1,3-Oxazoles, Diazobarbituric acid, Rh(II) catalysis, [2+3]-Cycloaddition, FACILE SYNTHESIS, RHODIUM(II)-CATALYZED REACTIONS, DIVERSE, RHODIUM CARBENOIDS",
author = "Martha Gecht and Grigory Kantin and Dmitry Dar'in and Mikhail Krasavin",
year = "2019",
month = oct,
day = "31",
doi = "10.1016/j.tetlet.2019.151120",
language = "English",
volume = "60",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "44",

}

RIS

TY - JOUR

T1 - A novel approach to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones via readily available diazobarbituric acid derivatives

AU - Gecht, Martha

AU - Kantin, Grigory

AU - Dar'in, Dmitry

AU - Krasavin, Mikhail

PY - 2019/10/31

Y1 - 2019/10/31

N2 - An alternative route from 1,3-disubstituted barbituric acids to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones was developed that features sulfonyl-azide-free (SAFE) diazo transfer and Rh2(esp)2-catalyzed cycloaddition of the resulting 5-diazobarbituric acids with aliphatic and aromatic nitriles. Besides being shorter compared to the previously described approaches, the method allows introduction of alkyl substituents at the 1,3-oxazole ring of the fused heterocyclic system.

AB - An alternative route from 1,3-disubstituted barbituric acids to biologically relevant oxazolo[5,4-d]pyrimidine-5,7-diones was developed that features sulfonyl-azide-free (SAFE) diazo transfer and Rh2(esp)2-catalyzed cycloaddition of the resulting 5-diazobarbituric acids with aliphatic and aromatic nitriles. Besides being shorter compared to the previously described approaches, the method allows introduction of alkyl substituents at the 1,3-oxazole ring of the fused heterocyclic system.

KW - 1,3-Oxazoles

KW - Diazobarbituric acid

KW - Rh(II) catalysis

KW - [2+3]-Cycloaddition

KW - FACILE SYNTHESIS

KW - RHODIUM(II)-CATALYZED REACTIONS

KW - DIVERSE

KW - RHODIUM CARBENOIDS

UR - http://www.scopus.com/inward/record.url?scp=85072731923&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2019.151120

DO - 10.1016/j.tetlet.2019.151120

M3 - Article

AN - SCOPUS:85072731923

VL - 60

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 44

M1 - 151120

ER -

ID: 49034163