Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative : synthesis, interaction with DNA, and antitumor activity. / Mikolaichuk, O. V.; Sharoyko, V. V.; Popova, E. A.; Protas, A. V.; Fonin, A. V.; Anufrikov, Yu A.; Malkova, A. M.; Shmaneva, N. T.; Ostrovskii, V. A.; Molchanov, O. E.; Maistrenko, D. N.; Semenov, K. N.
в: Russian Chemical Bulletin, Том 71, № 5, 05.2022, стр. 1050-1056.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative
T2 - synthesis, interaction with DNA, and antitumor activity
AU - Mikolaichuk, O. V.
AU - Sharoyko, V. V.
AU - Popova, E. A.
AU - Protas, A. V.
AU - Fonin, A. V.
AU - Anufrikov, Yu A.
AU - Malkova, A. M.
AU - Shmaneva, N. T.
AU - Ostrovskii, V. A.
AU - Molchanov, O. E.
AU - Maistrenko, D. N.
AU - Semenov, K. N.
N1 - Mikolaichuk, O.V., Sharoyko, V.V., Popova, E.A. et al. A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: synthesis, interaction with DNA, and antitumor activity. Russ Chem Bull 71, 1050–1056 (2022). https://doi.org/10.1007/s11172-022-3507-1
PY - 2022/5
Y1 - 2022/5
N2 - ({5-[4,6-Di(aziridin-1-yl)-1,3,5-triazin-2-yl]amino}-2,2-dimethyl-1,3-dioxan-5-yl)-methyl 2-(5-phenyl-2H-tetrazol-2-yl)acetate was synthesized and characterized. The interaction of the obtained tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative with DNA was studied by UV spectrophotometry, circular dichroism spectroscopy, and isothermal calorimetry. The values of binding constants (9.65·108 L mol−1, UV spectrophotometry; 4.08·108 L mol−1, isothermal calorimetry) of the 1,3,5-triazine derivative to DNA attests to efficient binding and formation of stable associates with the biopolymer. The addition of the tetrazole-containing 1,3,5-triazine derivative to a DNA solution has virtually no effect on the DNA melting point. The tetrazole-containing 1,3,5-triazine derivative exhibits a cytostatic effect on SK-HEP-1 human hepatic adenocarcinoma cells (half-maximal inhibitory concentration IC50 22.2 mmol L−1) and T98G human glioblastoma cells (IC50 44.9 mmol L−1).
AB - ({5-[4,6-Di(aziridin-1-yl)-1,3,5-triazin-2-yl]amino}-2,2-dimethyl-1,3-dioxan-5-yl)-methyl 2-(5-phenyl-2H-tetrazol-2-yl)acetate was synthesized and characterized. The interaction of the obtained tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative with DNA was studied by UV spectrophotometry, circular dichroism spectroscopy, and isothermal calorimetry. The values of binding constants (9.65·108 L mol−1, UV spectrophotometry; 4.08·108 L mol−1, isothermal calorimetry) of the 1,3,5-triazine derivative to DNA attests to efficient binding and formation of stable associates with the biopolymer. The addition of the tetrazole-containing 1,3,5-triazine derivative to a DNA solution has virtually no effect on the DNA melting point. The tetrazole-containing 1,3,5-triazine derivative exhibits a cytostatic effect on SK-HEP-1 human hepatic adenocarcinoma cells (half-maximal inhibitory concentration IC50 22.2 mmol L−1) and T98G human glioblastoma cells (IC50 44.9 mmol L−1).
KW - калориметрия
KW - антибиотики
KW - триазин
KW - днк
UR - http://www.scopus.com/inward/record.url?scp=85130378497&partnerID=8YFLogxK
U2 - 10.1007/s11172-022-3507-1
DO - 10.1007/s11172-022-3507-1
M3 - Article
AN - SCOPUS:85130378497
VL - 71
SP - 1050
EP - 1056
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 5
ER -
ID: 100130803