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A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde : Derivatization and microextraction of urea. / Shishov, Andrey; Shakirova, Firuza; Markova, Ulyana; Tolstoy, Petr; Bulatov, Andrey.
в: Journal of Molecular Liquids, Том 353, 118820, 01.05.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - A new hydrophobic deep eutectic solvent based on thymol and 4-(dimethylamino)benzaldehyde
T2 - Derivatization and microextraction of urea
AU - Shishov, Andrey
AU - Shakirova, Firuza
AU - Markova, Ulyana
AU - Tolstoy, Petr
AU - Bulatov, Andrey
N1 - Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - In this study, a deep eutectic solvent based on thymol as a hydrogen bond donor and 4-(dimethylamino)benzaldehyde as a hydrogen bond acceptor was synthesized and characterized by various methods for the first time. The new solvent is stable in the presence of water and can be considered as a hydrophobic extractant. In the presented work, this solvent was utilized for the derivatization and microextraction of urea for its determination in human urine and powdered milk samples. In the developed procedure, water-soluble analyte reacts with the hydrogen bond acceptor (4-(dimethylamino)benzaldehyde) with the formation of a colored derivative (Schiff base) followed by its mass-transfer into deep eutectic solvent phase. Combination of derivatization and extraction stages allowed to reduce sample pretreatment time and simplify the procedure for the determination of urea. The analysis time was 3 min. The limits of detection, calculated from the blank tests based on 3σ, were 0.1 mg L-1 for human urine and 2 mg kg−1 for powdered milk, RSD values were < 7 % and the enrichment factors were 24 and 23 for urine and milk samples. The procedure was successfully applied to the analysis of real samples.
AB - In this study, a deep eutectic solvent based on thymol as a hydrogen bond donor and 4-(dimethylamino)benzaldehyde as a hydrogen bond acceptor was synthesized and characterized by various methods for the first time. The new solvent is stable in the presence of water and can be considered as a hydrophobic extractant. In the presented work, this solvent was utilized for the derivatization and microextraction of urea for its determination in human urine and powdered milk samples. In the developed procedure, water-soluble analyte reacts with the hydrogen bond acceptor (4-(dimethylamino)benzaldehyde) with the formation of a colored derivative (Schiff base) followed by its mass-transfer into deep eutectic solvent phase. Combination of derivatization and extraction stages allowed to reduce sample pretreatment time and simplify the procedure for the determination of urea. The analysis time was 3 min. The limits of detection, calculated from the blank tests based on 3σ, were 0.1 mg L-1 for human urine and 2 mg kg−1 for powdered milk, RSD values were < 7 % and the enrichment factors were 24 and 23 for urine and milk samples. The procedure was successfully applied to the analysis of real samples.
KW - 4-(dimethylamino)benzaldehyde
KW - Extraction
KW - Hydrophobic deep eutectic solvent
KW - Thymol
KW - Urea, powdered milk, human urine
UR - http://www.scopus.com/inward/record.url?scp=85125465931&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/68a0757a-3ebe-301e-8bfe-150a850745e6/
U2 - 10.1016/j.molliq.2022.118820
DO - 10.1016/j.molliq.2022.118820
M3 - Article
AN - SCOPUS:85125465931
VL - 353
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 118820
ER -
ID: 93244520