Reaction of N-aryl substituted maleimides with aliphatic ketazines leads to the formation of 4,5-dihydropyridazin-3(2H)-ones in moderate yields. The reaction proceeds through 1,4-addition of an azine to the maleimide double bond, as confirmed by separation of the corresponding adducts in some cases, which are then converted into 4,5-dihydropyridazin-3(2H)-ones. In addition, the solid-state synthesis of 4,5-dihydropyridazin-3(2H)-ones is demonstrated for the first time.

Язык оригиналаанглийский
Страницы (с-по)3146-3149
Число страниц4
ЖурналTetrahedron Letters
Том52
Номер выпуска24
DOI
СостояниеОпубликовано - 15 июн 2011

    Предметные области Scopus

  • Биохимия
  • Поиск новых лекарств
  • Органическая химия

ID: 5019939