TY - JOUR

T1 - A hydrogel-based phantom of the brain tissue aimed at modelling complex metabolic transport processes

AU - Vanina, Anastasia S.

AU - Sychev, Alexander V.

AU - Lavrova, Anastasia I.

AU - Gavrilov, Pavel V.

AU - Andropova, Polina L.

AU - Grekhnyova, Elena V.

AU - Kudryavtseva, Tatiana N.

AU - Postnikov, Eugene B.

N1 - Vanina, A.S., Sychev, A.V., Lavrova, A.I. et al. A hydrogel-based phantom of the brain tissue aimed at modelling complex metabolic transport processes. Eur. Phys. J. Spec. Top. (2022). https://doi.org/10.1140/epjs/s11734-022-00733-0 Publisher Copyright: © 2022, The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022/12/9

Y1 - 2022/12/9

N2 - Amongst the modern problems of brain physiology, special attention is drawn to the transport processes in the brain’s extracellular space, which are crucial for understanding metabolic exchange, waste clearance, etc. At the same time, the complexity of direct registration of such processes in vivo forms a demand for developing artificial phantoms with properties resembling the brain’s parenchyma as models suited for testing different physical approaches to describing the respective spread of substances. Here we describe a novel hydrogel material with composition and structure adjusted to this goal. The phantom comprises a collagen network with the addition of lipids and catches water content close to that of the brain. The results of electron microscopy and computer tomography studies as well as exploration of peculiarities of the fluorescent marker spread argue that this compound material is prospective for its use for mimicking the brain’s tissue.

AB - Amongst the modern problems of brain physiology, special attention is drawn to the transport processes in the brain’s extracellular space, which are crucial for understanding metabolic exchange, waste clearance, etc. At the same time, the complexity of direct registration of such processes in vivo forms a demand for developing artificial phantoms with properties resembling the brain’s parenchyma as models suited for testing different physical approaches to describing the respective spread of substances. Here we describe a novel hydrogel material with composition and structure adjusted to this goal. The phantom comprises a collagen network with the addition of lipids and catches water content close to that of the brain. The results of electron microscopy and computer tomography studies as well as exploration of peculiarities of the fluorescent marker spread argue that this compound material is prospective for its use for mimicking the brain’s tissue.

UR - http://www.scopus.com/inward/record.url?scp=85143614663&partnerID=8YFLogxK

U2 - 10.1140/epjs/s11734-022-00733-0

DO - 10.1140/epjs/s11734-022-00733-0

M3 - Article

JO - European Physical Journal: Special Topics

JF - European Physical Journal: Special Topics

SN - 1951-6355

ER -