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A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry. / Peshkov, Anatoly A.; Makhmet, Azat; Bakulina, Olga; Kanov, Evgeny; Gainetdinov, Raul; Peshkov, Vsevolod A.; Dar'In, Dmitry; Krasavin, Mikhail.

в: Synthesis (Germany), Том 54, № 11, ss-2021-c0604-psp, 01.06.2022, стр. 2604-2615.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Peshkov, AA, Makhmet, A, Bakulina, O, Kanov, E, Gainetdinov, R, Peshkov, VA, Dar'In, D & Krasavin, M 2022, 'A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry', Synthesis (Germany), Том. 54, № 11, ss-2021-c0604-psp, стр. 2604-2615. https://doi.org/10.1055/s-0040-1719878

APA

Peshkov, A. A., Makhmet, A., Bakulina, O., Kanov, E., Gainetdinov, R., Peshkov, V. A., Dar'In, D., & Krasavin, M. (2022). A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry. Synthesis (Germany), 54(11), 2604-2615. [ss-2021-c0604-psp]. https://doi.org/10.1055/s-0040-1719878

Vancouver

Peshkov AA, Makhmet A, Bakulina O, Kanov E, Gainetdinov R, Peshkov VA и пр. A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry. Synthesis (Germany). 2022 Июнь 1;54(11):2604-2615. ss-2021-c0604-psp. https://doi.org/10.1055/s-0040-1719878

Author

Peshkov, Anatoly A. ; Makhmet, Azat ; Bakulina, Olga ; Kanov, Evgeny ; Gainetdinov, Raul ; Peshkov, Vsevolod A. ; Dar'In, Dmitry ; Krasavin, Mikhail. / A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry. в: Synthesis (Germany). 2022 ; Том 54, № 11. стр. 2604-2615.

BibTeX

@article{ec1070fd0d044e12aa85d6326c0c746d,
title = "A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry",
abstract = "Unsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amineassociated receptor 1 (TAAR1), an important target for CNS disease.",
keywords = "Castagnoli-Cushman, compound libraries, spirocyclic motifs, trace amine-associated receptor 1 agonists, SCAFFOLDS",
author = "Peshkov, {Anatoly A.} and Azat Makhmet and Olga Bakulina and Evgeny Kanov and Raul Gainetdinov and Peshkov, {Vsevolod A.} and Dmitry Dar'In and Mikhail Krasavin",
note = "Publisher Copyright: {\textcopyright} 2022 Georg Thieme Verlag. All rights reserved.",
year = "2022",
month = jun,
day = "1",
doi = "10.1055/s-0040-1719878",
language = "English",
volume = "54",
pages = "2604--2615",
journal = "Synthesis",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "11",

}

RIS

TY - JOUR

T1 - A General Approach to Spirocyclic Piperidines via Castagnoli-Cushman Chemistry

AU - Peshkov, Anatoly A.

AU - Makhmet, Azat

AU - Bakulina, Olga

AU - Kanov, Evgeny

AU - Gainetdinov, Raul

AU - Peshkov, Vsevolod A.

AU - Dar'In, Dmitry

AU - Krasavin, Mikhail

N1 - Publisher Copyright: © 2022 Georg Thieme Verlag. All rights reserved.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Unsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amineassociated receptor 1 (TAAR1), an important target for CNS disease.

AB - Unsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amineassociated receptor 1 (TAAR1), an important target for CNS disease.

KW - Castagnoli-Cushman

KW - compound libraries

KW - spirocyclic motifs

KW - trace amine-associated receptor 1 agonists

KW - SCAFFOLDS

UR - http://www.scopus.com/inward/record.url?scp=85124842392&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/49ce8671-1681-335a-89cd-5d9fd9f64868/

U2 - 10.1055/s-0040-1719878

DO - 10.1055/s-0040-1719878

M3 - Article

AN - SCOPUS:85124842392

VL - 54

SP - 2604

EP - 2615

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 11

M1 - ss-2021-c0604-psp

ER -

ID: 93077711