Результаты исследований: Научные публикации в периодических изданиях › статья
A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation. / Krasavin, M.; Sapegin, A.; Dorogov, M.
в: Tetrahedron Letters, Том 56, № 1, 2015, стр. 56-60.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation
AU - Krasavin, M.
AU - Sapegin, A.
AU - Dorogov, M.
PY - 2015
Y1 - 2015
N2 - © 2014 Elsevier B.V. All rights reserved. We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
AB - © 2014 Elsevier B.V. All rights reserved. We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
U2 - 10.1016/j.tetlet.2014.09.067
DO - 10.1016/j.tetlet.2014.09.067
M3 - Article
VL - 56
SP - 56
EP - 60
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 1
ER -
ID: 3988776