Standard

Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45. / Кондрашкина, А.М.; Антонец, Кирилл Сергеевич; Галкин, Алексей Петрович; Нижников, Антон Александрович.

в: МОЛЕКУЛЯРНАЯ БИОЛОГИЯ, Том 48, № 5, 2014, стр. 790-796.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Кондрашкина, АМ, Антонец, КС, Галкин, АП & Нижников, АА 2014, 'Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45', МОЛЕКУЛЯРНАЯ БИОЛОГИЯ, Том. 48, № 5, стр. 790-796.

APA

Кондрашкина, А. М., Антонец, К. С., Галкин, А. П., & Нижников, А. А. (2014). Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45. МОЛЕКУЛЯРНАЯ БИОЛОГИЯ, 48(5), 790-796.

Vancouver

Кондрашкина АМ, Антонец КС, Галкин АП, Нижников АА. Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45. МОЛЕКУЛЯРНАЯ БИОЛОГИЯ. 2014;48(5):790-796.

Author

Кондрашкина, А.М. ; Антонец, Кирилл Сергеевич ; Галкин, Алексей Петрович ; Нижников, Антон Александрович. / Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45. в: МОЛЕКУЛЯРНАЯ БИОЛОГИЯ. 2014 ; Том 48, № 5. стр. 790-796.

BibTeX

@article{3927aacd697649a487bac600d766187d,
title = "Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45",
abstract = "Previously, we described and characterized yeast non-chromosomal determinant [NSI+], possessing prion properties. This determinant causes a decrease in translation termination fidelity, which is phenotypically detectable as the nonsense suppression in the strains with decreased functional activity of eRF3 release factor. As a result of geneticscreen, we demonstrated that an increase in the expression of SUP45 encoding the eRF1 release factor (Sup45), masks, but does not eliminate nonsense suppression in the [NSI+] strains. In the present study, we first demonstrated the direct cause for the nonsense suppression in [NSI+] strains. We demonstrated that [NSI+] decreases the relative amounts of SUP45 mRNA that causes a decrease in the amounts of Sup45 protein that is detectable in the stationary growth phase. The data obtained suggest the structural protein of [NSI+] seems to be either a transcription factor or participates in the regulation of cellular mRNA stability.",
author = "А.М. Кондрашкина and Антонец, {Кирилл Сергеевич} and Галкин, {Алексей Петрович} and Нижников, {Антон Александрович}",
year = "2014",
language = "русский",
volume = "48",
pages = "790--796",
journal = "МОЛЕКУЛЯРНАЯ БИОЛОГИЯ",
issn = "0026-8984",
publisher = "Российская академия наук",
number = "5",

}

RIS

TY - JOUR

T1 - Прионоподобный детерминант [NSI+] Saccharomyces cerevisiae снижает экспрессию гена SUP45

AU - Кондрашкина, А.М.

AU - Антонец, Кирилл Сергеевич

AU - Галкин, Алексей Петрович

AU - Нижников, Антон Александрович

PY - 2014

Y1 - 2014

N2 - Previously, we described and characterized yeast non-chromosomal determinant [NSI+], possessing prion properties. This determinant causes a decrease in translation termination fidelity, which is phenotypically detectable as the nonsense suppression in the strains with decreased functional activity of eRF3 release factor. As a result of geneticscreen, we demonstrated that an increase in the expression of SUP45 encoding the eRF1 release factor (Sup45), masks, but does not eliminate nonsense suppression in the [NSI+] strains. In the present study, we first demonstrated the direct cause for the nonsense suppression in [NSI+] strains. We demonstrated that [NSI+] decreases the relative amounts of SUP45 mRNA that causes a decrease in the amounts of Sup45 protein that is detectable in the stationary growth phase. The data obtained suggest the structural protein of [NSI+] seems to be either a transcription factor or participates in the regulation of cellular mRNA stability.

AB - Previously, we described and characterized yeast non-chromosomal determinant [NSI+], possessing prion properties. This determinant causes a decrease in translation termination fidelity, which is phenotypically detectable as the nonsense suppression in the strains with decreased functional activity of eRF3 release factor. As a result of geneticscreen, we demonstrated that an increase in the expression of SUP45 encoding the eRF1 release factor (Sup45), masks, but does not eliminate nonsense suppression in the [NSI+] strains. In the present study, we first demonstrated the direct cause for the nonsense suppression in [NSI+] strains. We demonstrated that [NSI+] decreases the relative amounts of SUP45 mRNA that causes a decrease in the amounts of Sup45 protein that is detectable in the stationary growth phase. The data obtained suggest the structural protein of [NSI+] seems to be either a transcription factor or participates in the regulation of cellular mRNA stability.

UR - http://www.scopus.com/inward/record.url?scp=84930329211&partnerID=8YFLogxK

M3 - статья

C2 - 25842864

AN - SCOPUS:84930329211

VL - 48

SP - 790

EP - 796

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 5

ER -

ID: 9313733