Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
ОТСУТСТВИЕ ЦИКЛИНЗАВИСИМОЙ ФОСФОПРОТЕИНКИНАЗЫ PHO85P ПРИВОДИТ К НАРУШЕНИЮ РАСПРЕДЕЛЕНИЯ МИТОХОНДРИАЛЬНЫХ НУКЛЕОИДОВ У ДРОЖЖЕЙ SACCHAROMYCES CEREVISIAE. / Самбук, Е. В.; Физикова, А. Ю.; Захарова, К. В.; Смирнов, А. М.; Падкина, М. В.
в: Цитология, Том 47, № 10, 01.12.2005, стр. 917-924.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - ОТСУТСТВИЕ ЦИКЛИНЗАВИСИМОЙ ФОСФОПРОТЕИНКИНАЗЫ PHO85P ПРИВОДИТ К НАРУШЕНИЮ РАСПРЕДЕЛЕНИЯ МИТОХОНДРИАЛЬНЫХ НУКЛЕОИДОВ У ДРОЖЖЕЙ SACCHAROMYCES CEREVISIAE
AU - Самбук, Е. В.
AU - Физикова, А. Ю.
AU - Захарова, К. В.
AU - Смирнов, А. М.
AU - Падкина, М. В.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Cyclin-dependent phosphoprotein kinases (CDK) play essential role in the regulation of the progression through different phases of the cell cycle, being also involved in metabolic regulation and in actin cytoskeleton organization. The Saccharomyces cerevisiae CDK Pho85p is associated with 10 different cyclins and phosphorylates different substrates, among these transcription factors Pho4p and Gcn4p, and a protein involved in actin polymerization being a homologue of amphiphysin 1 of mammalian Rvs167p. It is known that mutations in the PHO85 gene have a multiple pleotropic effects, one of these effects being a rapid accumulation of mitochondrial [rho-] mutations observed on the background of gene PHO85 inactivation. In this study it was shown that the appearance of [rho-] clones is a result of some defects in mitochondrial nucleoid transmission from mother to bud cells.
AB - Cyclin-dependent phosphoprotein kinases (CDK) play essential role in the regulation of the progression through different phases of the cell cycle, being also involved in metabolic regulation and in actin cytoskeleton organization. The Saccharomyces cerevisiae CDK Pho85p is associated with 10 different cyclins and phosphorylates different substrates, among these transcription factors Pho4p and Gcn4p, and a protein involved in actin polymerization being a homologue of amphiphysin 1 of mammalian Rvs167p. It is known that mutations in the PHO85 gene have a multiple pleotropic effects, one of these effects being a rapid accumulation of mitochondrial [rho-] mutations observed on the background of gene PHO85 inactivation. In this study it was shown that the appearance of [rho-] clones is a result of some defects in mitochondrial nucleoid transmission from mother to bud cells.
UR - http://www.scopus.com/inward/record.url?scp=33745113250&partnerID=8YFLogxK
M3 - статья
C2 - 16711391
VL - 47
SP - 917
EP - 924
JO - Цитология
JF - Цитология
SN - 0041-3771
IS - 10
ER -
ID: 5120392