Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
СРАВНЕНИЕ ЧАСТОТ МУТАЦИИ CCR5DEL32 В ГЕНЕ CCR5 У РУССКИХ, ТУВИНЦЕВ, А ТАКЖЕ В ГРУППАХ ВИЧ-ИНФИЦИРОВАННЫХ ИНДИВИДУУМОВ. / Apryatin, S. A.; Rakhmanaliev, E. R.; Nikolaeva, I. A.; Ruban, S. V.; Vazykhova, F. G.; Klimov, E. A.; Sulimova, G. E.; Sidorovich, I. G.
в: ГЕНЕТИКА, Том 41, № 11, 01.12.2005, стр. 1559-1562.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - СРАВНЕНИЕ ЧАСТОТ МУТАЦИИ CCR5DEL32 В ГЕНЕ CCR5 У РУССКИХ, ТУВИНЦЕВ, А ТАКЖЕ В ГРУППАХ ВИЧ-ИНФИЦИРОВАННЫХ ИНДИВИДУУМОВ
AU - Apryatin, S. A.
AU - Rakhmanaliev, E. R.
AU - Nikolaeva, I. A.
AU - Ruban, S. V.
AU - Vazykhova, F. G.
AU - Klimov, E. A.
AU - Sulimova, G. E.
AU - Sidorovich, I. G.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 107), Tuvinians (n = 50), and HIV-infected individuals were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.
AB - The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 107), Tuvinians (n = 50), and HIV-infected individuals were examined for the presence of CCR5del32 mutation in the CCR5 gene. The CCR5del32 allele frequency in Russians and Tuvinians constituted 7.84 and 2%, respectively. Among HIV-1 infected individuals, two groups, of macrophage-tropic HIV-1 strain- and T-cell-tropic HIV-1 strain-infected were distinguished. The CCR5del32 allele frequency in the first group (6.45%) was lower than in the second one (8.73%). Statistical treatment of the HIV-1 infected individuals typing data showed that the difference in the CCR5del32 allele frequencies between the groups of sexually (macrophage-tropic) and parenterally (T-cell-tropic) infected individuals observed was within the limit of random deviation.
UR - http://www.scopus.com/inward/record.url?scp=33644829548&partnerID=8YFLogxK
UR - https://elibrary.ru/item.asp?id=9172892
M3 - статья
C2 - 16358723
AN - SCOPUS:33644829548
VL - 41
SP - 1559
EP - 1562
JO - ГЕНЕТИКА
JF - ГЕНЕТИКА
SN - 0016-6758
IS - 11
ER -
ID: 115018600