Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Ингибиторы натрий-глюкозного ко-транспортера 2-го типа: успешная погоня за двумя зайцами. / Перепеч, Никита Борисович; Михайлова, Ирина Евгеньевна.
в: РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ, Том 26, № S2, 2021, стр. 54-62.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Ингибиторы натрий-глюкозного ко-транспортера 2-го типа:
T2 - успешная погоня за двумя зайцами
AU - Перепеч, Никита Борисович
AU - Михайлова, Ирина Евгеньевна
N1 - Publisher Copyright: © 2021, Silicea-Poligraf. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-scale randomized clinical trials evaluating the efficacy of SGLT2 inhibitors are discussed. We showed the beneficial effect of SGLT-2 inhibitors on the risk of cardiovascular events in patients with type 2 diabetes. In addition, an evidence of the ability of dapagliflozin and empagliflozin to improve the prognosis of patients with HF with reduced ejection fraction without diabetes are presented. The evidence and mechanisms of the nephroprotective action of SGLT2 inhibitors in patients with diabetes and HF are considered.
AB - The review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-scale randomized clinical trials evaluating the efficacy of SGLT2 inhibitors are discussed. We showed the beneficial effect of SGLT-2 inhibitors on the risk of cardiovascular events in patients with type 2 diabetes. In addition, an evidence of the ability of dapagliflozin and empagliflozin to improve the prognosis of patients with HF with reduced ejection fraction without diabetes are presented. The evidence and mechanisms of the nephroprotective action of SGLT2 inhibitors in patients with diabetes and HF are considered.
KW - Diabetes
KW - Heart failure
KW - Prognosis
KW - Sodium-glucose cotransporter type 2 inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85117688050&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ffe8141c-27ef-33d4-8e72-e7ed04a60a7e/
U2 - 10.15829/1560-4071-2021-4534
DO - 10.15829/1560-4071-2021-4534
M3 - статья
AN - SCOPUS:85117688050
VL - 26
SP - 54
EP - 62
JO - РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ
JF - РОССИЙСКИЙ КАРДИОЛОГИЧЕСКИЙ ЖУРНАЛ
SN - 1560-4071
IS - S2
ER -
ID: 88426009