Introduction. In recent years, CHF is considered as a multiple hormonal and metabolic defi ciency syndrome accompanied by anabolic/catabolic imbalance and echocardiographic abnormalities. One of the components of this imbalance is the change in the axis of growth hormone-insulinlike growth factor-1 (IGF-1). In this connection, we aimed to evaluate the possible role of IGF-1 in patients with DT2. In this study, we found that patients with DT2 had signifi cantly lower level of serum IGF-1 than the control group. Purpose. To assess the relationship between the serum IGF-1 level and echocardiographic parameters in DT2 patients without clinical manifestations of CHF. Materials and methods. The study included 75 patients with DT2 of both sexes aged from 43 to 86 years. Serum IGF-1 level was determined with ELISA. Results and discussion. There were negative associations between IGF-1 and cystatin C, left ventricular mass index (LVMI) and left ventricular ejection fraction. Multiple linear regression analysis confi rmed the association between IGF-1 and LVMI, which suggests that IGF-1 may be one of the predictors of left ventricular hypertrophy and CHF. Conclusion. Occurrence of left ventricular hypertrophy and development of CHF in diabetes are promoted by the presence of many risk factors. Their infl uence consistently complements each other as the disease progresses (age, renal dysfunction). IGF-1 may be one of the potential predictors of left ventricular hypertrophy.