Исследование гиполипидемических и остеопротекторных свойств 8α-аналогов стероидных эстрогенов

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Исследование гиполипидемических и остеопротекторных свойств 8α-аналогов стероидных эстрогенов. / Eschenko, N. D.; Putilina, F. E.; Galkina, O. V.; Vilkova, V. A.; Zacharova, L. I.; Fidarov, A. F.; Morozkina, S. N.; Shavva, A. G.

в: БИОМЕДИЦИНСКАЯ ХИМИЯ, Том 61, № 6, 2015, стр. 724-730.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{1d509775a7364f6d80b4a20b862d956b,

title = "Исследование гиполипидемических и остеопротекторных свойств 8α-аналогов стероидных эстрогенов",

abstract = "The aim of this work was to study the ability of some estrogen 8α-analogues, that have CH3-group in the C-3 position, exhibit osteoprotective and cholesterolemic effects. The properties of these analogues was comparisoned with effects of native estradiol and 17α-ethynylestradiol (EE). We showed that compouns 3 ((d,l)-17β-acethoxy-3-methoxy-8α-estra-1,3,5(10)-triene) and 4 ((d,l)-3-methoxy-8α-estra1,3,5(10)-triene-17-one) had the same osteoprotective and cholesterolemic effects as EE. The utherotropic effects of compound 3 and EE were the same, while the utherotropic activity of 17-keto derivative (compound 4) was higher than effect of EE. The osteoprotective and cholesterolemic effects of compounds 5 and 6 (d- or 1-17β-acethoxy-3-methoxy-13-ethyl-8α-gone-1,3,5(10)-triene) were approximately the same, however the utherotropic action of these compounds was different: the compound 5 had significantly lower activity, but the compound 6 had the same effect in comparison with EE. Thus, all studied estrogen 8α-analogues may be used as basic constructions for structural modifications which is necessary as medications with while spectrum of biological properties.",

keywords = "Osteoprotective and cholesterolemic effects, Synthetic estrogen analogues",

author = "Eschenko, {N. D.} and Putilina, {F. E.} and Galkina, {O. V.} and Vilkova, {V. A.} and Zacharova, {L. I.} and Fidarov, {A. F.} and Morozkina, {S. N.} and Shavva, {A. G.}",

year = "2015",

doi = "10.18097/PBMC20156106724",

language = "русский",

volume = "61",

pages = "724--730",

journal = "БИОМЕДИЦИНСКАЯ ХИМИЯ",

issn = "2310-6905",

publisher = "Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича",

number = "6",

}

RIS

TY - JOUR

T1 - Исследование гиполипидемических и остеопротекторных свойств 8α-аналогов стероидных эстрогенов

AU - Eschenko, N. D.

AU - Putilina, F. E.

AU - Galkina, O. V.

AU - Vilkova, V. A.

AU - Zacharova, L. I.

AU - Fidarov, A. F.

AU - Morozkina, S. N.

AU - Shavva, A. G.

PY - 2015

Y1 - 2015

N2 - The aim of this work was to study the ability of some estrogen 8α-analogues, that have CH3-group in the C-3 position, exhibit osteoprotective and cholesterolemic effects. The properties of these analogues was comparisoned with effects of native estradiol and 17α-ethynylestradiol (EE). We showed that compouns 3 ((d,l)-17β-acethoxy-3-methoxy-8α-estra-1,3,5(10)-triene) and 4 ((d,l)-3-methoxy-8α-estra1,3,5(10)-triene-17-one) had the same osteoprotective and cholesterolemic effects as EE. The utherotropic effects of compound 3 and EE were the same, while the utherotropic activity of 17-keto derivative (compound 4) was higher than effect of EE. The osteoprotective and cholesterolemic effects of compounds 5 and 6 (d- or 1-17β-acethoxy-3-methoxy-13-ethyl-8α-gone-1,3,5(10)-triene) were approximately the same, however the utherotropic action of these compounds was different: the compound 5 had significantly lower activity, but the compound 6 had the same effect in comparison with EE. Thus, all studied estrogen 8α-analogues may be used as basic constructions for structural modifications which is necessary as medications with while spectrum of biological properties.

AB - The aim of this work was to study the ability of some estrogen 8α-analogues, that have CH3-group in the C-3 position, exhibit osteoprotective and cholesterolemic effects. The properties of these analogues was comparisoned with effects of native estradiol and 17α-ethynylestradiol (EE). We showed that compouns 3 ((d,l)-17β-acethoxy-3-methoxy-8α-estra-1,3,5(10)-triene) and 4 ((d,l)-3-methoxy-8α-estra1,3,5(10)-triene-17-one) had the same osteoprotective and cholesterolemic effects as EE. The utherotropic effects of compound 3 and EE were the same, while the utherotropic activity of 17-keto derivative (compound 4) was higher than effect of EE. The osteoprotective and cholesterolemic effects of compounds 5 and 6 (d- or 1-17β-acethoxy-3-methoxy-13-ethyl-8α-gone-1,3,5(10)-triene) were approximately the same, however the utherotropic action of these compounds was different: the compound 5 had significantly lower activity, but the compound 6 had the same effect in comparison with EE. Thus, all studied estrogen 8α-analogues may be used as basic constructions for structural modifications which is necessary as medications with while spectrum of biological properties.

KW - Osteoprotective and cholesterolemic effects

KW - Synthetic estrogen analogues

UR - http://www.scopus.com/inward/record.url?scp=84965191904&partnerID=8YFLogxK

U2 - 10.18097/PBMC20156106724

DO - 10.18097/PBMC20156106724

M3 - статья

C2 - 26716744

VL - 61

SP - 724

EP - 730

JO - БИОМЕДИЦИНСКАЯ ХИМИЯ

JF - БИОМЕДИЦИНСКАЯ ХИМИЯ

SN - 2310-6905

IS - 6

ER -

ID: 4001623