TY - JOUR

T1 - Роль белков, взаимодействующих с факторами терминации трансляции eRF1 и eRF3, в регуляции трансляции и прионизации

AU - Журавлева, Галина Анатольевна

AU - Бондарев, Станислав Александрович

AU - Землянко, Ольга Михайловна

AU - Москаленко, Светлана Евгеньевна

PY - 2022/3/1

Y1 - 2022/3/1

N2 - The review discusses the role that proteins interacting with the translation termination factors eRF1 and eRF3 play in the control of protein synthesis and prionization. These proteins interact not only with each other, but also with many other proteins involved in controlling the efficiency of translation termination, and associate translation termination with other cell processes. The termination of translation is directly related not only to translation re-initiation and ribosome recycling, but also to mRNA stability and protein quality control. This connection is ensured by the interaction of eRF1 and eRF3 with proteins participating in various cell metabolic processes, such as mRNA transport from the nucleus into the cytoplasm (Dbp5/DDX19 and Gle1), ribosome recycling (Rli1/ABCE1), mRNA degradation (Upf proteins), and translation initiation (Pab1/PABP). In addition to genetic control, there is epigenetic control of translation termination. This mechanism is associated with prion polymerization of the Sup35 protein to form the [PSI^(+)] prion. The maintenance of the [PSI^(+)] prion, like other yeast prions, requires the operation of a system of molecular chaperones and protein sorting factors. The review considers in detail the interaction of the translation termination factors with proteins involved in various cellular processes.

AB - The review discusses the role that proteins interacting with the translation termination factors eRF1 and eRF3 play in the control of protein synthesis and prionization. These proteins interact not only with each other, but also with many other proteins involved in controlling the efficiency of translation termination, and associate translation termination with other cell processes. The termination of translation is directly related not only to translation re-initiation and ribosome recycling, but also to mRNA stability and protein quality control. This connection is ensured by the interaction of eRF1 and eRF3 with proteins participating in various cell metabolic processes, such as mRNA transport from the nucleus into the cytoplasm (Dbp5/DDX19 and Gle1), ribosome recycling (Rli1/ABCE1), mRNA degradation (Upf proteins), and translation initiation (Pab1/PABP). In addition to genetic control, there is epigenetic control of translation termination. This mechanism is associated with prion polymerization of the Sup35 protein to form the [PSI^(+)] prion. The maintenance of the [PSI^(+)] prion, like other yeast prions, requires the operation of a system of molecular chaperones and protein sorting factors. The review considers in detail the interaction of the translation termination factors with proteins involved in various cellular processes.

KW - PABP

KW - SUP35

KW - SUP45

KW - Upf

KW - [PSI^(+)]

KW - eRF1

KW - eRF3

KW - prion

KW - protein quality control

KW - translation termination

UR - http://www.scopus.com/inward/record.url?scp=85127865081&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/be3db909-68cc-3191-be8e-2cdb3cc344ab/

U2 - 10.31857/s002689842201013x

DO - 10.31857/s002689842201013x

M3 - статья

VL - 56

SP - 206

EP - 226

JO - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

JF - МОЛЕКУЛЯРНАЯ БИОЛОГИЯ

SN - 0026-8984

IS - 2

ER -