TY - JOUR

T1 - Возможности терапевтической коррекции патологии носоглотки, ассоциированной с COVID-19, у детей в амбулаторных условиях

AU - Golovacheva, Ekaterina Georgievna

AU - Afanasyeva, O I

AU - Goncharova, E S

AU - Bykovskaya, A G

AU - Davletgareeva, D V

AU - Apryatina, V A

PY - 2021

Y1 - 2021

N2 - OBJECTIVE: To evaluate the therapeutic and preventive efficacy of the drug with antiviral and immunotropic activity Cytovir-3 in children with COVID-19 on an outpatient basis.MATERIAL AND METHODS: A retrospective analysis the treatment of 52 pediatric patients aged 1 to 17 years with a confirmed new coronavirus infection SARS-CoV-2 with the drug Cytovir-3 was carried out. 28 people, contacts in the family, received the drug for prophylactic purposes. Clinical observation of patients was carried out with an assessment of the severity and duration of fever, the anosmia, catarrhal symptoms in the nasopharynx and analysis indicator of saturation. In the control group, there were 27 patients of the same age who received the medicine Umifenovir and 25 contact family members who did not receive the medicine for prophylactic purposes.RESULTS: The use of Cytovir-3 in the COVID-19 treatment in children led to a decrease in intoxication symptoms 3.2-3.4 days after taking the medicine, a significant reduction of anosmia period recovery time, and elimination of the pathogen according to PCR analysis. The patients receiving the drug did not have ENT- complications and did not require hospitalization. Prophylactic administration of the drug in contact family members statistically significantly reduced the likelihood of developing the disease 3.6 times. The clinical efficacy and feasibility of using Cytovir-3 in the treatment and prevention of new coronavirus infection in patients of different ages has been shown.

AB - OBJECTIVE: To evaluate the therapeutic and preventive efficacy of the drug with antiviral and immunotropic activity Cytovir-3 in children with COVID-19 on an outpatient basis.MATERIAL AND METHODS: A retrospective analysis the treatment of 52 pediatric patients aged 1 to 17 years with a confirmed new coronavirus infection SARS-CoV-2 with the drug Cytovir-3 was carried out. 28 people, contacts in the family, received the drug for prophylactic purposes. Clinical observation of patients was carried out with an assessment of the severity and duration of fever, the anosmia, catarrhal symptoms in the nasopharynx and analysis indicator of saturation. In the control group, there were 27 patients of the same age who received the medicine Umifenovir and 25 contact family members who did not receive the medicine for prophylactic purposes.RESULTS: The use of Cytovir-3 in the COVID-19 treatment in children led to a decrease in intoxication symptoms 3.2-3.4 days after taking the medicine, a significant reduction of anosmia period recovery time, and elimination of the pathogen according to PCR analysis. The patients receiving the drug did not have ENT- complications and did not require hospitalization. Prophylactic administration of the drug in contact family members statistically significantly reduced the likelihood of developing the disease 3.6 times. The clinical efficacy and feasibility of using Cytovir-3 in the treatment and prevention of new coronavirus infection in patients of different ages has been shown.

KW - Adolescent

KW - Antiviral Agents/therapeutic use

KW - COVID-19/prevention & control

KW - Child

KW - Child, Preschool

KW - Humans

KW - Infant

KW - Outpatients

KW - Post-Exposure Prophylaxis

KW - Retrospective Studies

KW - COVID-19 Drug Treatment

U2 - 10.17116/otorino20218606169

DO - 10.17116/otorino20218606169

M3 - статья

C2 - 34964333

VL - 86

SP - 69

EP - 73

JO - ВЕСТНИК ОТОРИНОЛАРИНГОЛОГИИ

JF - ВЕСТНИК ОТОРИНОЛАРИНГОЛОГИИ

SN - 0042-4668

IS - 6

ER -