Purpose of the study. To evaluate the psycho-emotional state in patients with chronic viral hepatitis C before and after treatment with bicyclol. Materials and methods. The study included 124 male patients with chronic hepatitis C aged 20 to 52 years (average 34.7 ± 6.5). The patients were randomized into 2 groups: group I, including 83 patients with mild to moderate liver fibrosis (F1-2 according to METAVIR); and group II – 41 patients with severe liver fibrosis (F3 according to METAVIR). After antiviral therapy with direct antiviral agents, patients in each group were divided into 2 subgroups: an experimental group, which was prescribed the bicyclol to potentiate the anti-inflammatory effect, and a control group – without pathogenetic therapy. The psycho-emotional state was evaluated using the “Well-being, activity, mood” methodology. Results. As a result of complex etiopathogenetic therapy, a decrease in liver stiffness was observed in both patients with moderate and severe liver fibrosis. In patients of the experimental subgroup with moderate liver fibrosis, a decrease in liver density was observed from 7.10 kPa [6.70; 8.70] to 5.80 kPa [5.60; 7.00] (p = 0.008), and in the control subgroup – up to 6.40 kPa [5.80; 7.40] (p = 0.03), while in the experimental subgroup the decrease in liver density was significantly more pronounced (p = 0.04). When taking the questionnaire “Well-being, activity, mood” by patients with mild and moderate liver fibrosis before starting antiviral therapy, the final scores were in the normal range: total score 5.77 [5.53; 6.03], “well-being” indicator 5.80 [5.60; 6.20], “activity” indicator 5.30 [5.00; 5.60], “mood” indicator 6.10 [6.00; 6.20]. At the same time, patients with severe fibrosis had statistically significantly lower results for the studied indicators (p