Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
ВЛИЯНИЕ СТРУКТУРНЫХ ПОЛИМОРФИЗМОВ ГЕНОВ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА, АНГИОТЕНЗИНОГЕНА, ЭНДОТЕЛИАЛЬНОЙ СИНТЕТАЗЫ ОКСИДА АЗОТА И РЕЦЕПТОРА БРАДИКИНИНА 2-ГО ТИПА НА СОСТОЯНИЕ МИОКАРДЗ У СПОРТСМЕНОВ И БОЛЬНЫХ ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮ. / Shneider, O. V.; Obrezan, A. G.; Makeeva, E. D.; Stupnitskii, A. A.; Spivak, I. M.; Mikhel'son, V. M.
в: Tsitologiia, Том 46, № 1, 2004, стр. 69-78.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - ВЛИЯНИЕ СТРУКТУРНЫХ ПОЛИМОРФИЗМОВ ГЕНОВ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА, АНГИОТЕНЗИНОГЕНА, ЭНДОТЕЛИАЛЬНОЙ СИНТЕТАЗЫ ОКСИДА АЗОТА И РЕЦЕПТОРА БРАДИКИНИНА 2-ГО ТИПА НА СОСТОЯНИЕ МИОКАРДЗ У СПОРТСМЕНОВ И БОЛЬНЫХ ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮ.
AU - Shneider, O. V.
AU - Obrezan, A. G.
AU - Makeeva, E. D.
AU - Stupnitskii, A. A.
AU - Spivak, I. M.
AU - Mikhel'son, V. M.
PY - 2004
Y1 - 2004
N2 - We investigated the role of gene polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen, endothelial NO (eNO) synthase, and bradykinin receptor B2 in determining the cardiovascular system structure and function in hypertension and "athletic heart" syndrome. Using a PCR-based method, 114 hypertensive patients and 94 athletes were genotyped for I/D polymorphism of ACE, M235T angiotensinogen (ANG), Glu298 Asp endothelial synthase (eNOS), and type 2 receptor for bradykinin (BDKR2). Echocardiography and a 24 hour blood pressure monitoring being performed. The (+)-allel of BDKR2 gene was associated with the left ventricular hypertrophy and greater wall thickness in athletes and hypertensive subjects. The hypertensive patients, that were homozygous for Glu298 allele of eNOS, demonstrated a lower level of diastolic blood pressure than did those with Glu298 Asp and Asp298 Asp genotypes. At the same time, the ACE and AND gene polymorphisms displayed no association with the cardiac structure and function.
AB - We investigated the role of gene polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen, endothelial NO (eNO) synthase, and bradykinin receptor B2 in determining the cardiovascular system structure and function in hypertension and "athletic heart" syndrome. Using a PCR-based method, 114 hypertensive patients and 94 athletes were genotyped for I/D polymorphism of ACE, M235T angiotensinogen (ANG), Glu298 Asp endothelial synthase (eNOS), and type 2 receptor for bradykinin (BDKR2). Echocardiography and a 24 hour blood pressure monitoring being performed. The (+)-allel of BDKR2 gene was associated with the left ventricular hypertrophy and greater wall thickness in athletes and hypertensive subjects. The hypertensive patients, that were homozygous for Glu298 allele of eNOS, demonstrated a lower level of diastolic blood pressure than did those with Glu298 Asp and Asp298 Asp genotypes. At the same time, the ACE and AND gene polymorphisms displayed no association with the cardiac structure and function.
KW - Adult
KW - Alleles
KW - Angiotensinogen/genetics
KW - Blood Pressure
KW - Female
KW - Genetic Predisposition to Disease
KW - Humans
KW - Hypertension/genetics
KW - Hypertrophy, Left Ventricular/genetics
KW - Male
KW - Middle Aged
KW - Myocardium/pathology
KW - Nitric Oxide Synthase/genetics
KW - Peptidyl-Dipeptidase A/genetics
KW - Polymorphism, Genetic
KW - Polymorphism, Restriction Fragment Length
KW - Receptor, Bradykinin B2/genetics
KW - Sports Medicine
UR - http://www.scopus.com/inward/record.url?scp=3342975490&partnerID=8YFLogxK
M3 - статья
C2 - 15112434
VL - 46
SP - 69
EP - 78
JO - Цитология
JF - Цитология
SN - 0041-3771
IS - 1
ER -
ID: 87920857