TY - JOUR

T1 - АПРОБАЦИЯ И ВАЛИДАЦИЯ РУССКОЙ ВЕРСИИ ОПРОСНИКА ДЛЯ ОЦЕНКИ КАЧЕСТВА ЖИЗНИ У БОЛЬНЫХ ПЕРВИЧНЫМ ГИПЕРПАРАТИРЕОЗОМ - PHPQOL

AU - Гладкова, Инна Николаевна

AU - Русаков, Владимир Федорович

AU - Черников, Роман Анатольевич

AU - Карелина, Юлия Валерьевна

AU - Никитина, Татьяна Павловна

AU - Ефремов, Сергей Михайлович

AU - Ионова, Татьяна Ивановна

N1 - Publisher Copyright: © 2021 Media Sphera Publishing Group. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/12

Y1 - 2021/2/12

N2 - BACKGROUND: Quality of life (QoL) assessment before and after surgical treatment in patients with primary hyperparathyroidism (PHTP) may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient' condition after surgery, including in real clinical practice. AIM: The aim of the study was to validate and test the Russian version of the PHPQoL questionnaire for assessment of the quality of life (QoL) in patients with primary hyperparathyroidism (PHPT) for further application in clinical practice and research in Russia. MATERIALS AND METHODS: The linguistic and cultural adaptation of the PHPQoL questionnaire was carried out in accordance with international guidelines. Psychometric properties of the tool, namely, its reliability, validity and sensitivity were tested in the focus group of patients with PHPT RESULTS: In the whole, 65 patients with PHPT were involved into the study (mean age - 52.3 ± 10.5 years, 97% - women): 67.7% patients were symptomatic, 35.4% patients had moderate or severe hypercalcemia. All the patients filled out the Russian version of PHPQoL before parathyroidectomy. One third of patients filled out the Russian version of PHPQoL twice - before surgery and 3 months after surgery. Satisfactory external and content validity of the Russian version of PHPQoL was demonstrated. Its stable structure confirmed satisfactory construct validity of the questionnaire. The ability of the tool to determine differences in severity of symptoms/problems due to PHPT before and after treatment was revealed. The positive effect of the surgery on QoL in PHPT patients was shown. CONCLUSION: The results obtained during the study confirm that the Russian version of PHPQoL is a reliable, valid and sensitive tool. Feasibility and applicability of its use in research and clinical practice in Russian endocrinology settings has been demonstrated.

AB - BACKGROUND: Quality of life (QoL) assessment before and after surgical treatment in patients with primary hyperparathyroidism (PHTP) may be useful for comprehensive evaluation of the treatment effect, as well as for monitoring of the patient' condition after surgery, including in real clinical practice. AIM: The aim of the study was to validate and test the Russian version of the PHPQoL questionnaire for assessment of the quality of life (QoL) in patients with primary hyperparathyroidism (PHPT) for further application in clinical practice and research in Russia. MATERIALS AND METHODS: The linguistic and cultural adaptation of the PHPQoL questionnaire was carried out in accordance with international guidelines. Psychometric properties of the tool, namely, its reliability, validity and sensitivity were tested in the focus group of patients with PHPT RESULTS: In the whole, 65 patients with PHPT were involved into the study (mean age - 52.3 ± 10.5 years, 97% - women): 67.7% patients were symptomatic, 35.4% patients had moderate or severe hypercalcemia. All the patients filled out the Russian version of PHPQoL before parathyroidectomy. One third of patients filled out the Russian version of PHPQoL twice - before surgery and 3 months after surgery. Satisfactory external and content validity of the Russian version of PHPQoL was demonstrated. Its stable structure confirmed satisfactory construct validity of the questionnaire. The ability of the tool to determine differences in severity of symptoms/problems due to PHPT before and after treatment was revealed. The positive effect of the surgery on QoL in PHPT patients was shown. CONCLUSION: The results obtained during the study confirm that the Russian version of PHPQoL is a reliable, valid and sensitive tool. Feasibility and applicability of its use in research and clinical practice in Russian endocrinology settings has been demonstrated.

KW - PHPQoL questionnaire

KW - Primary hyperparathyroidism

KW - Quality of life

KW - Russian version

KW - Female

KW - Humans

KW - Hyperparathyroidism, Primary/diagnosis

KW - Quality of Life

KW - Reproducibility of Results

KW - Russia

KW - Surveys and Questionnaires

UR - http://www.scopus.com/inward/record.url?scp=85101442207&partnerID=8YFLogxK

U2 - 10.14341/probl12714

DO - 10.14341/probl12714

M3 - статья

C2 - 33586391

AN - SCOPUS:85101442207

VL - 67

SP - 41

EP - 51

JO - ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ

JF - ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ

SN - 0375-9660

IS - 1

ER -