TY - JOUR

T1 - Эффективность комбинации метформина и интраназального инсулина для коррекции метаболических и гормональных нарушений у взрослых самцов крыс с метаболическим синдромом, вызванным нарушением грудного вскармливания

AU - Derkach, K.V.

AU - Ivantsov, A.O.

AU - Basova, N.E.

AU - Shpakov, A.O.

N1 - Export Date: 01 November 2025; Cited By: 0; Correspondence Address: K.V. Derkach; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russian Federation; email: derkatch_k@list.ru

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Limiting or temporally stopping breastfeeding can lead to the development of metabolic syndrome in adulthood, which requires the development of approaches for its prevention and correction. One such approach is treatment with metformin or intranasal insulin. Since the targets of these agents differ and may complement each other, it has been suggested that their combined use could be effective. AIM: To study the effect of a four-week co-administration of metformin (orally, 120 mg/kg/day) and intranasal insulin (1.2 IU/kg/day) in male rats with metabolic syndrome, induced by breastfeeding disruption on postnatal days 19–21, on their metabolic and hormonal parameters. MATERIALS AND METHODS: The study treatment was compared with monotherapy using the same drugs. RESULTS: It was found that adult male rats with disrupted breastfeeding developed obesity, dyslipidemia, hyperlepti-nemia, impaired glucose tolerance, and a reduction in the number of β-cells and the area of pancreatic islets, which are characteristic of metabolic syndrome. Long-term treatment with metformin and its combination with intranasal insulin partially or fully normalized body weight, abdominal fat, and metabolic and hormonal parameters, with the restorative effect of combination treatment on such parameters as body weight, fat mass, glucose tolerance, and blood glycated hemoglobin levels being more pronounced than with metformin alone. CONCLUSIONS: The results of the study support the use of a combination of metformin and intranasal insulin to normal-ize metabolic and hormonal parameters in metabolic syndrome induced by breastfeeding disruption in early days of life. © 2024 Elsevier B.V., All rights reserved.

AB - BACKGROUND: Limiting or temporally stopping breastfeeding can lead to the development of metabolic syndrome in adulthood, which requires the development of approaches for its prevention and correction. One such approach is treatment with metformin or intranasal insulin. Since the targets of these agents differ and may complement each other, it has been suggested that their combined use could be effective. AIM: To study the effect of a four-week co-administration of metformin (orally, 120 mg/kg/day) and intranasal insulin (1.2 IU/kg/day) in male rats with metabolic syndrome, induced by breastfeeding disruption on postnatal days 19–21, on their metabolic and hormonal parameters. MATERIALS AND METHODS: The study treatment was compared with monotherapy using the same drugs. RESULTS: It was found that adult male rats with disrupted breastfeeding developed obesity, dyslipidemia, hyperlepti-nemia, impaired glucose tolerance, and a reduction in the number of β-cells and the area of pancreatic islets, which are characteristic of metabolic syndrome. Long-term treatment with metformin and its combination with intranasal insulin partially or fully normalized body weight, abdominal fat, and metabolic and hormonal parameters, with the restorative effect of combination treatment on such parameters as body weight, fat mass, glucose tolerance, and blood glycated hemoglobin levels being more pronounced than with metformin alone. CONCLUSIONS: The results of the study support the use of a combination of metformin and intranasal insulin to normal-ize metabolic and hormonal parameters in metabolic syndrome induced by breastfeeding disruption in early days of life. © 2024 Elsevier B.V., All rights reserved.

KW - breastfeeding

KW - glucose tolerance

KW - hyperleptinemia

KW - intranasal insulin

KW - metabolic syndrome

KW - metformin

KW - glycated hemoglobin

KW - insulin

KW - abdominal fat

KW - adult

KW - animal experiment

KW - animal model

KW - B lymphocyte

KW - body weight

KW - breast feeding

KW - controlled study

KW - dyslipidemia

KW - fat mass

KW - hemoglobin blood level

KW - impaired glucose tolerance

KW - male

KW - metabolic syndrome X

KW - monotherapy

KW - nonhuman

KW - obesity

KW - pancreas islet

KW - prevention

KW - rat

KW - review

U2 - 10.17816/RCF626249

DO - 10.17816/RCF626249

M3 - статья

VL - 22

SP - 289

EP - 300

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

SN - 1683-4100

IS - 3

ER -