Purpose. To evaluate brain changes based on resting-state functional MRI graphs in patients with multiple sclerosis in response to comprehensive rehabilitation measures. Materials and methods. A total of 30 patients with relapsing-remitting multiple sclerosis who underwent comprehensive inpatient rehabilitation participated in the study. Resting-state functional MRI was performed at two control points. The diagnosis of multiple sclerosis was confirmed clinically. Results. In response to comprehensive rehabilitation, all patients showed increased integration indices in the orbitofrontal cortex of the right frontal lobe (T=3.03; p