Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Значение оценки минеральной плотности костей с помощью двухэнергетической рентгеновской абсорбциометрии для прогнозирования сердечно-сосудистой смертности у пациентов, получающих лечение гемодиализом. / Мазуренко, С.О.; Накатис, Я.А.; Енькин, А.А.; Старосельский, К.Г.; Васильев, А.Н.; Мазуренко, О.Г.; Соин, П.В.; Ермолаева, Л.Г.; Иванов, И.Г,.
в: ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV), Том 92, № 6, 06.2020, стр. 33-36.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Значение оценки минеральной плотности костей с помощью двухэнергетической рентгеновской абсорбциометрии для прогнозирования сердечно-сосудистой смертности у пациентов, получающих лечение гемодиализом
AU - Мазуренко, С.О.
AU - Накатис, Я.А.
AU - Енькин, А.А.
AU - Старосельский, К.Г.
AU - Васильев, А.Н.
AU - Мазуренко, О.Г.
AU - Соин, П.В.
AU - Ермолаева, Л.Г.
AU - Иванов, И.Г,
N1 - Publisher Copyright: © 2020 Consilium Medikum. All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Aim. Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. Materials and methods. A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men - 265, women - 251, mean age 44.8±11.4 years) who were observed for 5.7±3.2 years. Before inclusion in the study, in all patients was analyzed bone mineral density using dual-energy X-ray absorptiometry in three standard departments: Lumbar vertebrae, proximal femur and distal forearm. The probability analysis of the outcome was carried out using the Kaplan- Meier method and Cox. results. During follow-up period 111 (21.5%) patients died, 50.5% from cardiovascular events. Survival analysis by Kaplan-Meier method allowed to prove the increased risk of death from cardiovascular pathology in hemodailysis patients with low bone mineral density of all evaluated areas. Step-by-step multivariate Cox regression analysis showed that the T score of the femur, showing the difference of BMD of the patient with normal value of BMD for young adult, had the greatest prognostic significance. conclusion. Reduced bone mineral density in patients receiving hemodialysis is associated with an increased risk of death from cardiovascular disease. Dual energy x-ray absorptiometry can be used for assessment of this risk.
AB - Aim. Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. Materials and methods. A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men - 265, women - 251, mean age 44.8±11.4 years) who were observed for 5.7±3.2 years. Before inclusion in the study, in all patients was analyzed bone mineral density using dual-energy X-ray absorptiometry in three standard departments: Lumbar vertebrae, proximal femur and distal forearm. The probability analysis of the outcome was carried out using the Kaplan- Meier method and Cox. results. During follow-up period 111 (21.5%) patients died, 50.5% from cardiovascular events. Survival analysis by Kaplan-Meier method allowed to prove the increased risk of death from cardiovascular pathology in hemodailysis patients with low bone mineral density of all evaluated areas. Step-by-step multivariate Cox regression analysis showed that the T score of the femur, showing the difference of BMD of the patient with normal value of BMD for young adult, had the greatest prognostic significance. conclusion. Reduced bone mineral density in patients receiving hemodialysis is associated with an increased risk of death from cardiovascular disease. Dual energy x-ray absorptiometry can be used for assessment of this risk.
KW - гемодиализ, остеопороз, минеральная плотность костей, смертность, выживаемость, денситометрия
KW - ALL-CAUSE
KW - CHRONIC KIDNEY-DISEASE
KW - bone mineral density
KW - densitometry
KW - hemodialysis
KW - mortality
KW - osteoporosis
KW - survival
UR - https://ter-arkhiv.ru/0040-3660/article/view/34980
UR - https://www.mendeley.com/catalogue/ac698b23-2ec1-36db-95fd-d7fbc6e98e53/
UR - http://www.scopus.com/inward/record.url?scp=85098236101&partnerID=8YFLogxK
U2 - 10.26442/00403660.2020.06.000277
DO - 10.26442/00403660.2020.06.000277
M3 - статья
C2 - 33346490
AN - SCOPUS:85098236101
VL - 92
SP - 33
EP - 36
JO - ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV)
JF - ТЕРАПЕВТИЧЕСКИЙ АРХИВ (TERAPEVTICHESKII ARKHIV)
SN - 0040-3660
IS - 6
ER -
ID: 60619654