Hyperostosis in adults against the background of autosomal dominant osteopetrosis, ADOP) is a rare skeletal pathology characterized by the formation of excess bone tissue, a high probability of fractures and neurological symptoms. There is isolated information in the literature about vertebral fractures on the background of OP. Clinical cases of secondary spinal canal stenosis and spinal instability are presented. The study emphasizes the importance of conducting timely morphological and genetic studies to verify the diagnosis. Since there is no etiopathogenetic treatment for ADOP yet, patients with fractures undergo symptomatic treatment and syndromic surgical interventions