TY - JOUR

T1 - Кожный зуд и его влияние на качество жизни у пациентов с хронической болезнью почек, находящихся на гемодиализе

AU - Лемешевская, Ольга Игоревна

AU - Толкач, Алексей Дмитриевич

AU - Паршина, Екатерина Викторовна

AU - Никитина, Татьяна Павловна

AU - Зулькарнаев , Алексей Батыргараевич

AU - Тутин, Алексей Павлович

AU - Лисова, Мария Николаевна

AU - Ионова, Татьяна Ивановна

PY - 2026/6/29

Y1 - 2026/6/29

N2 - Background. Chronic kidney disease-associated pruritus (CKD-aP) can significantly impair quality of life by negatively affecting patient psycho-emotional well-being and sleep quality, while also increasing the risk of hospitalizations and mortality. In Russia, this issue remains understudied. Objective: to assess the prevalence of pruritus and its impact on various aspects of quality of life in a Russian cohort of patients with CKD receiving maintenance hemodialysis. Methods. The cross-sectional study included 225 patients from two dialysis centers with who has been receiving hemodialysis for more than 3 months. The presence and severity of CKD-aP were assessed using the following validated instruments: WI-NRS, Skindex-16, Itch MOS, and the 5-D Itch Scale. Results. CKD-aP was identified in 52% of the patients, with 16% [95% CI: 11; 21] experiencing moderate-to-very severe pruritus (WI-NRS ≥4). The most commonly affected body areas were the back (53%), head (35%), shins (32%), and thighs (25%). Patients with CKD-aP, particularly those with moderate-to-severe pruritus, demonstrated more pronounced sleep disturbances. Sleep Problem Index II (SPI-II) scores were 13.3 [Q1-Q3: 0.0; 33.3] in patients without pruritus, 20 [6.7; 33.3] in those with mild pruritus, and 33.3 [20.0; 60.0] in those with moderate-to-severe pruritus (p=0.001). Patients with moderate-to-severe pruritus also had significantly higher Skindex-16 total and subscales score compared to those with mild pruritus: total score 20.7 [8.9; 35.3] vs. 7.4 [2.8; 15.5] (p

AB - Background. Chronic kidney disease-associated pruritus (CKD-aP) can significantly impair quality of life by negatively affecting patient psycho-emotional well-being and sleep quality, while also increasing the risk of hospitalizations and mortality. In Russia, this issue remains understudied. Objective: to assess the prevalence of pruritus and its impact on various aspects of quality of life in a Russian cohort of patients with CKD receiving maintenance hemodialysis. Methods. The cross-sectional study included 225 patients from two dialysis centers with who has been receiving hemodialysis for more than 3 months. The presence and severity of CKD-aP were assessed using the following validated instruments: WI-NRS, Skindex-16, Itch MOS, and the 5-D Itch Scale. Results. CKD-aP was identified in 52% of the patients, with 16% [95% CI: 11; 21] experiencing moderate-to-very severe pruritus (WI-NRS ≥4). The most commonly affected body areas were the back (53%), head (35%), shins (32%), and thighs (25%). Patients with CKD-aP, particularly those with moderate-to-severe pruritus, demonstrated more pronounced sleep disturbances. Sleep Problem Index II (SPI-II) scores were 13.3 [Q1-Q3: 0.0; 33.3] in patients without pruritus, 20 [6.7; 33.3] in those with mild pruritus, and 33.3 [20.0; 60.0] in those with moderate-to-severe pruritus (p=0.001). Patients with moderate-to-severe pruritus also had significantly higher Skindex-16 total and subscales score compared to those with mild pruritus: total score 20.7 [8.9; 35.3] vs. 7.4 [2.8; 15.5] (p

KW - chronic kidney disease

KW - dialysis

KW - pruritus

KW - quality of life

KW - questionnaire

UR - https://www.mendeley.com/catalogue/73823a99-2f12-317c-9501-dd3a5c71ee0f/

U2 - 10.28996/2618-9801-2026-2-213-226

DO - 10.28996/2618-9801-2026-2-213-226

M3 - статья

VL - 28

SP - 213

EP - 226

JO - Nephrology and Dialysis

JF - Nephrology and Dialysis

SN - 1680-4422

IS - 2

ER -