СТРЕССОРНАЯ ДЕСТАБИЛИЗАЦИЯ ГЕНОМА В КЛЕТКАХ ПРЕФРОНТАЛЬНОЙ КОРЫ, ГИППОКАМПА И КОСТНОГО МОЗГА КРЫС С КОНТРАСТНОЙ ВОЗБУДИМОСТЬЮ НЕРВНОЙ СИСТЕМЫ

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СТРЕССОРНАЯ ДЕСТАБИЛИЗАЦИЯ ГЕНОМА В КЛЕТКАХ ПРЕФРОНТАЛЬНОЙ КОРЫ, ГИППОКАМПА И КОСТНОГО МОЗГА КРЫС С КОНТРАСТНОЙ ВОЗБУДИМОСТЬЮ НЕРВНОЙ СИСТЕМЫ. / Павлова, Марина Борисовна; Vaido, A. I.; Khlebaeva, D. A.А.; Daev, E. V.; Dyuzhikova, N. A.

в: ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА, Том 18, № 4, 09.10.2020, стр. 457-465.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{9057b9d2c1ea437994d60e918e069af5,

title = "СТРЕССОРНАЯ ДЕСТАБИЛИЗАЦИЯ ГЕНОМА В КЛЕТКАХ ПРЕФРОНТАЛЬНОЙ КОРЫ, ГИППОКАМПА И КОСТНОГО МОЗГА КРЫС С КОНТРАСТНОЙ ВОЗБУДИМОСТЬЮ НЕРВНОЙ СИСТЕМЫ",

abstract = "We studied changes in the stability of the genome in cells of two brain regions (prefrontal cortex and hippocampus), as well as in the bone marrow of rats with a hereditary high and low thresholds of excitability of the nervous system (strains HT and LT, respectively) after prolonged exposure with emotional-pain stressor. To study the reactivity of the brain cells genome, phosphorylated histone γ-H2AX (γ-H2AX phospho Ser139) was used. The level of mitotic disturbances in bone marrow cells was also assessed. Between the animals of the control groups, there were no interstrain differences in the studied parameters. Stress exposure increases the immunoreactivity to γ-H2AX phospho Ser139 of the prefrontal cortex cells and the level of chromosomal aberrations in bone marrow cells in animals of both strains. In cells of the dentate gyrus of the hippocampus, a specific increase in immunoreactivity to γ-H2AX phospho Ser139 was revealed in rats of the low-excitable HT strain. The relationship between the reaction of cells of this zone of hippocampus to the stressor exposure with the hereditary level of excitability of the nervous system of animals is discussed.",

keywords = "Bone marrow, Chromosomal aberrations, Double-strand breaks, Excitability, Hippocampus, Prefrontal cortex, Rats, Stress, γ-H2AX, Bone marrow, Chromosomal aberrations, Double-strand breaks, Excitability, Hippocampus, Prefrontal cortex, Rats, Stress, γ-H2AX",

author = "Павлова, {Марина Борисовна} and Vaido, {A. I.} and Khlebaeva, {D. A.А.} and Daev, {E. V.} and Dyuzhikova, {N. A.}",

year = "2020",

month = oct,

day = "9",

doi = "10.17816/ecogen43853",

language = "русский",

volume = "18",

pages = "457--465",

journal = "ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА",

issn = "1811-0932",

publisher = "Эко-Вектор",

number = "4",

}

RIS

TY - JOUR

T1 - СТРЕССОРНАЯ ДЕСТАБИЛИЗАЦИЯ ГЕНОМА В КЛЕТКАХ ПРЕФРОНТАЛЬНОЙ КОРЫ, ГИППОКАМПА И КОСТНОГО МОЗГА КРЫС С КОНТРАСТНОЙ ВОЗБУДИМОСТЬЮ НЕРВНОЙ СИСТЕМЫ

AU - Павлова, Марина Борисовна

AU - Vaido, A. I.

AU - Khlebaeva, D. A.А.

AU - Daev, E. V.

AU - Dyuzhikova, N. A.

PY - 2020/10/9

Y1 - 2020/10/9

N2 - We studied changes in the stability of the genome in cells of two brain regions (prefrontal cortex and hippocampus), as well as in the bone marrow of rats with a hereditary high and low thresholds of excitability of the nervous system (strains HT and LT, respectively) after prolonged exposure with emotional-pain stressor. To study the reactivity of the brain cells genome, phosphorylated histone γ-H2AX (γ-H2AX phospho Ser139) was used. The level of mitotic disturbances in bone marrow cells was also assessed. Between the animals of the control groups, there were no interstrain differences in the studied parameters. Stress exposure increases the immunoreactivity to γ-H2AX phospho Ser139 of the prefrontal cortex cells and the level of chromosomal aberrations in bone marrow cells in animals of both strains. In cells of the dentate gyrus of the hippocampus, a specific increase in immunoreactivity to γ-H2AX phospho Ser139 was revealed in rats of the low-excitable HT strain. The relationship between the reaction of cells of this zone of hippocampus to the stressor exposure with the hereditary level of excitability of the nervous system of animals is discussed.

AB - We studied changes in the stability of the genome in cells of two brain regions (prefrontal cortex and hippocampus), as well as in the bone marrow of rats with a hereditary high and low thresholds of excitability of the nervous system (strains HT and LT, respectively) after prolonged exposure with emotional-pain stressor. To study the reactivity of the brain cells genome, phosphorylated histone γ-H2AX (γ-H2AX phospho Ser139) was used. The level of mitotic disturbances in bone marrow cells was also assessed. Between the animals of the control groups, there were no interstrain differences in the studied parameters. Stress exposure increases the immunoreactivity to γ-H2AX phospho Ser139 of the prefrontal cortex cells and the level of chromosomal aberrations in bone marrow cells in animals of both strains. In cells of the dentate gyrus of the hippocampus, a specific increase in immunoreactivity to γ-H2AX phospho Ser139 was revealed in rats of the low-excitable HT strain. The relationship between the reaction of cells of this zone of hippocampus to the stressor exposure with the hereditary level of excitability of the nervous system of animals is discussed.

KW - Bone marrow

KW - Chromosomal aberrations

KW - Double-strand breaks

KW - Excitability

KW - Hippocampus

KW - Prefrontal cortex

KW - Rats

KW - Stress

KW - γ-H2AX

KW - Bone marrow

KW - Chromosomal aberrations

KW - Double-strand breaks

KW - Excitability

KW - Hippocampus

KW - Prefrontal cortex

KW - Rats

KW - Stress

KW - γ-H2AX

UR - http://www.scopus.com/inward/record.url?scp=85099614970&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/0cbfcb67-405b-34d3-9554-730cbd491a64/

U2 - 10.17816/ecogen43853

DO - 10.17816/ecogen43853

M3 - статья

AN - SCOPUS:85099614970

VL - 18

SP - 457

EP - 465

JO - ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА

JF - ЭКОЛОГИЧЕСКАЯ ГЕНЕТИКА

SN - 1811-0932

IS - 4

ER -

ID: 73463040