TY - JOUR

T1 - Взаимосвязь модифицируемых факторов риска с показателями артериальной жесткости и сосудистым возрастом у пациентов с артериальной гипертензией

AU - Tuktarov, Arthur M.

AU - Kazanceva, Tat'yana S.

AU - Filippov, Aleksandr E.

AU - Obrezan, Andrey G.

N1 - Publisher Copyright: © 2021 Stolichnaya Izdatelskaya Kompaniya. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/3

Y1 - 2021/3/3

N2 - Aim. To study the relationship of modifiable risk factors (RF) with indicators of arterial stiffness and vascular age based on the contour analysis of the pulse wave velocity in hypertensive patients. Material and methods. The material of the study was the data from a survey of patients undergoing clinical observation at the polyclinic of MMC SOGAZ. A total of 107 patients were examined, in which 70 were men and 37 were women. The average age was 52.3 }18.29. Photoplethysmography was used as a special research method, performed using the AngioScan-01 diagnostic complex. The main indicators used to evaluate the stiffness of large vessels were: Stiffness index (SI), reflection index (RI), augmentation index (Alp75), age index (AGI), pulse wave types (PV) and vascular age (VA). Results. The mean values of arterial stiffness indices in patients with essential arterial hypertension (AH) and healthy individuals (control) had significant differences. The mean SI, Alp75, and VA values in the group of patients with AH were 7.8 }1.03, 7.0 }14.44 and 50.8 }15.93 versus 7.2 }1.73, 0.5 }18.02 and 43.8 }16.94, respectively (p<0.05). In both groups, a strong inverse correlation of passport age with C-type PV was revealed (r=0.74, p<0.01), which reflected the dynamics of a gradual age-dependent decrease in vascular compliance. The average VA value in the control group was 63.1 }16.99 years with an average passport age of 59.5 }8.79 years, which significantly differed from VA in hypertensive patients (p<0,05). Overweight, hypercholesterolemia, elevated low-density lipoprotein levels, lack of adequate antihypertensive control, and left ventricular diastolic dysfunction were significantly associated with early vascular (arterial) aging. Conclusion. Patients with hypertension, in addition to high blood pressure, significantly differ from normotensive control in terms of arterial stiffness. The lack of control over modifiable RF of patients with hypertension is associated with early vascular aging.

AB - Aim. To study the relationship of modifiable risk factors (RF) with indicators of arterial stiffness and vascular age based on the contour analysis of the pulse wave velocity in hypertensive patients. Material and methods. The material of the study was the data from a survey of patients undergoing clinical observation at the polyclinic of MMC SOGAZ. A total of 107 patients were examined, in which 70 were men and 37 were women. The average age was 52.3 }18.29. Photoplethysmography was used as a special research method, performed using the AngioScan-01 diagnostic complex. The main indicators used to evaluate the stiffness of large vessels were: Stiffness index (SI), reflection index (RI), augmentation index (Alp75), age index (AGI), pulse wave types (PV) and vascular age (VA). Results. The mean values of arterial stiffness indices in patients with essential arterial hypertension (AH) and healthy individuals (control) had significant differences. The mean SI, Alp75, and VA values in the group of patients with AH were 7.8 }1.03, 7.0 }14.44 and 50.8 }15.93 versus 7.2 }1.73, 0.5 }18.02 and 43.8 }16.94, respectively (p<0.05). In both groups, a strong inverse correlation of passport age with C-type PV was revealed (r=0.74, p<0.01), which reflected the dynamics of a gradual age-dependent decrease in vascular compliance. The average VA value in the control group was 63.1 }16.99 years with an average passport age of 59.5 }8.79 years, which significantly differed from VA in hypertensive patients (p<0,05). Overweight, hypercholesterolemia, elevated low-density lipoprotein levels, lack of adequate antihypertensive control, and left ventricular diastolic dysfunction were significantly associated with early vascular (arterial) aging. Conclusion. Patients with hypertension, in addition to high blood pressure, significantly differ from normotensive control in terms of arterial stiffness. The lack of control over modifiable RF of patients with hypertension is associated with early vascular aging.

KW - Arterial hypertension

KW - Arterial stiffness

KW - Early vascular aging

KW - Risk factors

KW - Vascular age

KW - arterial stiffness

KW - risk factors

KW - MANAGEMENT

KW - PREDICTOR

KW - vascular age

KW - GUIDELINES

KW - early vascular aging

KW - AORTIC STIFFNESS

KW - EXERCISE

KW - arterial hypertension

KW - PRESSURE

KW - TASK-FORCE

KW - DYSFUNCTION

KW - ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85103549669&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/6678817a-881d-34ce-9bfb-cf600e30abde/

U2 - 10.20996/1819-6446-2021-02-12

DO - 10.20996/1819-6446-2021-02-12

M3 - статья

AN - SCOPUS:85103549669

VL - 17

SP - 42

EP - 48

JO - Rational Pharmacotherapy in Cardiology

JF - Rational Pharmacotherapy in Cardiology

SN - 1819-6446

IS - 1

ER -