Background. The direct pathophysiological effects of depression on the components of MS lead to the development of atherosclerosis risk factors. The use of antidepressants minimizes life-threatening clinical manifestations of coronary artery disease and the formation of a pathological stereotype of eating behavior. Objective. To study the specific activity of antidepressants on induced metabolic syndrome in spontaneously hypertensive animals. Design and methods. Work performed on rats (males line SHR). The intact group was on a standard diet, the control group and the groups that received the drugs (amitriptyline and intraludial vaccine, 16.2 mg/kg and 1.7 mg/kg respectively, once a day for five weeks) - on the “cafeteria diet”. Results. With the induction of MS in the groups receiving the diet “cafeteria diet” there was an increase in body weight by 5 % relative to intact animals, fasting glucose levels exceeding 7.2 ± 0.9 mmol/l, a tendency to an increase in serum cholesterol (CS) blood more than 2.0 ± 0.1 mmol/l. Against the background of the use of the studied drugs, there was a statistically significant reduction in feed intake by 77 and 59 % and a decrease in body weight relative to the control group by 10 and 8 % respectively. Significant dynamics of indicators of GTT, cholesterol, TG, LDL and HDL with the use of antidepressants was not observed. Conclusion. A pronounced anti-bulimic effect of the studied drugs, manifested in a decrease in feed intake, a decrease in body weight, was noted. Positive dynamics on carbohydrate and lipid exchanges, indicators of blood pressure, behavioral activity of animals was not observed.