The aim of our study was to evaluate the efficacy and safety of taking a universal hepatoprotector based on ursodeoxycholic acid in patients with cholelithiasis who underwent cholecystectomy. Materials and methods. The study involved 52 patients with cholelithiasis and changes in the lipid spectrum who underwent elective laparoscopic cholecystectomy. The patients were divided into 2 groups of 26 people, the first group received treatment with ursodeoxycholic acid after surgical treatment, the second group received only non-drug recommendations. All patients before the operation and 3 months after it underwent a biochemical blood test, lipidogram, ultrasound of the abdominal cavity, magnetic resonance cholangiopancreatography, gastroenterological complaints, quality of life were evaluated. Results. In patients taking ursodeoxycholic acid, the severity of gastroenterological complaints after cholecystectomy was less pronounced, blood lipid profile indicators improved. Conclusion. The appointment of a hepatoprotector based on ursodeoxycholic acid makes it possible to eliminate the phe-nomena of biliary dyspepsia, improves the blood lipid spectrum. The drug demonstrates high efficacy and safety, it can be recommended for the curation of patients with cholelithiasis who have undergone cholecystectomy.