Introduction. The course of pregnancy against the background of chronic pyelonephritis is associated with a high risk of complications both on the part of the expectant mother and the fetus. The peculiarities of intrauterine development of the child in pregnancy complicated by chronic pyelonephritis (delayed intrauterine development and chronic fetal hypoxia against the background of placental insufficiency due to infectious process, gestosis, anemia, etc.), as well as the non-physiological course of the birth act have a negative impact on the adaptation of newborn children in the postnatal period, leading to neonatal morbidity and early childhood disability. The complicated course of pregnancy and labor in women suffering from chronic pyelonephritis, which has a negative impact on the development of the fetus and the health of the newborn child, necessitates the search and inclusion in the dispensary monitoring of this contingent of women of new non-medicamentous ways to reduce perinatal risks in order to preserve the health of mother and child. The aim of the study: evaluate the effect of osteopathic correction on the outcome of pregnancy and childbirth in women with chronic pyelonephritis. Materials and methods. In a prospective controlled randomized study conducted from January 2018 to January 2025g on the basis of the medical clinic LLC «Institute of Osteopathy Mokhov» were included 180 pregnant women with chronic pyelonephritis without renal failure at the age of 25–45 years. A comparison group of 60 healthy pregnant women was also formed. All pregnant women with chronic pyelonephritis, depending on the correction method used, were divided by simple randomization using a random number generator into three groups: the main group (60 people) and two control groups of 60 people each. Patients of the main group received standard drug therapy according to the approved clinical recommendations and osteopathic correction of somatic dysfunctions (3 procedures with an interval of 10–14 days). Patients in the first control group received standard drug therapy. Patients of the second control group, along with drug therapy, used physical exercises 2 times a week for 1,5 months, as prescribed by a physician of therapeutic physical training (LPK). Healthy pregnant women were dynamically monitored. In all women, the term and method of delivery, the body weight of the newborn child, and Apgar scale scores at 1 and 5 minutes after birth were assessed (using data extracted from medical records). Results. Osteopathic correction in the complex therapy of chronic pyelonephritis in pregnant women in comparison with isolated standard drug therapy and with the use of exercises of physical therapy in combination with standard drug therapy statistically significantly (p