Purpose of the study. Was to identify additional prognostic factors in patients with renal cell cancer metastases to the liver influencing survival rates. Patients and methods. In patients with renal cell cancer (RCC) metastases to the liver, a search for new prognostic factors affecting survival rates is needed. The retrospective analysis of data of 141 patients with liver metastases of RCC treated at the Moscow City Oncological Hospital No. 62 in Moscow and the City Clinical Oncological Dispensary (St. Petersburg) from 2006 to 2022 was carried out. Men prevailed (66.7 %), age 60–74 years in 51.1 %, low-differentiated tumors (56,0 %) and multiple metastases (83.7 %) were detected more often. The study investigated clinical and morphological prognostic factors influencing survival rates in patients with liver metastases of RCC. Statistical analysis was performed using Statistica 10.0 software packages (StatSoft, USA) by constructing Kaplan-Meier curves and survival tables, building a mathematical model of survival. Results. The 3- and 5-year OS in patients with liver metastases of RCC ( n = 141) was 42.4 % and 23.7 %, respectively, with a median OS of 22 months. In a single-factor analysis in patients with renal cancer metastases to the liver, it was found that ECOG status ( p < 0.001), histological subtype ( p = 0.01) had a negative impact on survival rates, Fuhrman tumor differentiation ( p < 0.001), type ( p < 0.001) and number of metastases ( p = 0.024), metastases to lymph nodes ( p = 0.006), IMDC prognosis ( p < 0.001), nephrectomy ( p < 0.001) and metastasectomy ( p = 0.0006). In multivariate analysis, ECOG status [HR = 10.09 (95 % CI = 1.31–77], histological subtype [HR = 3,45 (95 % CI = 1.77–6.71], lymph node metastasis [HR = 1.93 (95 % CI = 1.21–3.07], hemoglobin level [HR = 2.44 (95 % CI=1.39–4.29], and undergoing nephrectomy [HR = 2.10 (95 % CI = 1.16–3.79] were additional predictors affecting OS rates in patients with liver metastases of RCC. Conclusion. In our study, ECOG status, histological subtype, lymph node metastasis, hemoglobin level and nephrectomy were additional independent prognostic factors affecting AE rates in patients with RCC liver metastases. Further studies are needed to identify additional prognostic factors in patients with RCC liver metastases to improve the efficacy of personalized treatment.