Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Подавление роста опухолей, полученных при ксенотрансплантации клеток аденокарциномы толстой кишки человека. / Davydov-Sinitsyn, A. P.; Bazhenova, O. V.; Liskovykh, M. A.; Ponomartsev, S. V.; Rykov, I. V.; Koshkin, S. A.; Orlova, R. V.; Tomilin, A. N.; Tolkunova, E. N.
в: Цитология, Том 57, № 4, 2015, стр. 278-285.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Подавление роста опухолей, полученных при ксенотрансплантации клеток аденокарциномы толстой кишки человека
AU - Davydov-Sinitsyn, A. P.
AU - Bazhenova, O. V.
AU - Liskovykh, M. A.
AU - Ponomartsev, S. V.
AU - Rykov, I. V.
AU - Koshkin, S. A.
AU - Orlova, R. V.
AU - Tomilin, A. N.
AU - Tolkunova, E. N.
N1 - Copyright: Copyright 2015 Medline is the source for the citation and abstract of this record.
PY - 2015
Y1 - 2015
N2 - Previously we've described the obtainment of a subpopulation of cancer stem cells from a human colorec- tal carcinoma cell line MIP101. These cells possess elevated clonogenic and tumorigenic capacities. According to our data, depletion of stem compartment in a cancer cell population blocks its tumorigenicity. The current work is dedicated to the comparison of tumorigenic potential between cell populations with enriched or depleted stem compartment. We show that tumor growth following xenografting of enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we report a method to obtain a cell population with high Oct4 promoter expression within the MIP101 colorectal carcinoma cell line and to eliminate these cells from the population in vitro as well as in vivo.
AB - Previously we've described the obtainment of a subpopulation of cancer stem cells from a human colorec- tal carcinoma cell line MIP101. These cells possess elevated clonogenic and tumorigenic capacities. According to our data, depletion of stem compartment in a cancer cell population blocks its tumorigenicity. The current work is dedicated to the comparison of tumorigenic potential between cell populations with enriched or depleted stem compartment. We show that tumor growth following xenografting of enriched stem cell population can be suppressed by intramuscular injections of ganciclovir. Thus, we report a method to obtain a cell population with high Oct4 promoter expression within the MIP101 colorectal carcinoma cell line and to eliminate these cells from the population in vitro as well as in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84943350308&partnerID=8YFLogxK
M3 - статья
C2 - 26349245
AN - SCOPUS:84943350308
VL - 57
SP - 278
EP - 285
JO - Цитология
JF - Цитология
SN - 0041-3771
IS - 4
ER -
ID: 39207127