388 patients with diseases and traumas of nervous system have been surveyed and treated. Asthenic disorders were found at 65 % of patients with traumatic brain injuries and at 70.1 % of patients with traumas and chronic diseases of peripheral nervous system. Was revealed, that frequency of occurrence asthenia at patients with traumatic brain injuries eventually decreases, but at patients with traumas and chronic diseases of peripheral nervous system - eventually increases; thus clinical expressiveness of asthenic disorders does not vary authentically. Etiopathogenetic factors do not render influence on character and expressiveness of asthenic parameters. The differentiated complex approach and duration of treatment have crucial importance in success of therapy.