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Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов. / Tikhonova, T. B.; Magazanik, L. G.; Tikhonov, D. B.

в: Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk, Том 96, № 3, 03.2010, стр. 237-246.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Tikhonova, TB, Magazanik, LG & Tikhonov, DB 2010, 'Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов.', Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk, Том. 96, № 3, стр. 237-246.

APA

Tikhonova, T. B., Magazanik, L. G., & Tikhonov, D. B. (2010). Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов. Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk, 96(3), 237-246.

Vancouver

Tikhonova TB, Magazanik LG, Tikhonov DB. Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов. Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk. 2010 Март;96(3):237-246.

Author

Tikhonova, T. B. ; Magazanik, L. G. ; Tikhonov, D. B. / Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов. в: Rossiǐskii fiziologicheskiǐ zhurnal imeni I.M. Sechenova / Rossiǐskaia akademiia nauk. 2010 ; Том 96, № 3. стр. 237-246.

BibTeX

@article{dc9c3fb821904612a3e98931db2afd94,
title = "Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов.",
abstract = "It is well known that ion composition significantly affects action of various pharmacological agents. In the present work we studied influence of external sodium on the block of Ca2+ -permeable AMPA receptor channels by dicationic derivative of phenylcyclohexyl IEM-1925. Experiments were performed on native receptors of giant striatal interneurones isolated from the rat brain slices. Registrations were done with the aid of whole-cell patch clamp technique. We found that partial substitution of external sodium by sucrose potentiated the blocking action of IEM-1925. The effect was voltage-dependent, being more pronounced at hyperpolarized voltages. The analysis of kinetics of the IEM-1925 action demonstrated that lowering of external sodium facilitated blocking action, whereas stability of the drug-channel complex remained unaffected. We conclude that the current carrying sodium ions compete with blocking cation IEM-1925 for an intrapore binding site.",
author = "Tikhonova, {T. B.} and Magazanik, {L. G.} and Tikhonov, {D. B.}",
year = "2010",
month = mar,
language = "русский",
volume = "96",
pages = "237--246",
journal = "РОССИЙСКИЙ ФИЗИОЛОГИЧЕСКИЙ ЖУРНАЛ ИМ. И.М. СЕЧЕНОВА",
issn = "0869-8139",
publisher = "Издательство {"}Наука{"}",
number = "3",

}

RIS

TY - JOUR

T1 - Влияние ионного состава внешней среды на блокаду ионных каналов АМРА рецепторов.

AU - Tikhonova, T. B.

AU - Magazanik, L. G.

AU - Tikhonov, D. B.

PY - 2010/3

Y1 - 2010/3

N2 - It is well known that ion composition significantly affects action of various pharmacological agents. In the present work we studied influence of external sodium on the block of Ca2+ -permeable AMPA receptor channels by dicationic derivative of phenylcyclohexyl IEM-1925. Experiments were performed on native receptors of giant striatal interneurones isolated from the rat brain slices. Registrations were done with the aid of whole-cell patch clamp technique. We found that partial substitution of external sodium by sucrose potentiated the blocking action of IEM-1925. The effect was voltage-dependent, being more pronounced at hyperpolarized voltages. The analysis of kinetics of the IEM-1925 action demonstrated that lowering of external sodium facilitated blocking action, whereas stability of the drug-channel complex remained unaffected. We conclude that the current carrying sodium ions compete with blocking cation IEM-1925 for an intrapore binding site.

AB - It is well known that ion composition significantly affects action of various pharmacological agents. In the present work we studied influence of external sodium on the block of Ca2+ -permeable AMPA receptor channels by dicationic derivative of phenylcyclohexyl IEM-1925. Experiments were performed on native receptors of giant striatal interneurones isolated from the rat brain slices. Registrations were done with the aid of whole-cell patch clamp technique. We found that partial substitution of external sodium by sucrose potentiated the blocking action of IEM-1925. The effect was voltage-dependent, being more pronounced at hyperpolarized voltages. The analysis of kinetics of the IEM-1925 action demonstrated that lowering of external sodium facilitated blocking action, whereas stability of the drug-channel complex remained unaffected. We conclude that the current carrying sodium ions compete with blocking cation IEM-1925 for an intrapore binding site.

UR - http://www.scopus.com/inward/record.url?scp=77954724474&partnerID=8YFLogxK

M3 - статья

C2 - 20535994

AN - SCOPUS:77954724474

VL - 96

SP - 237

EP - 246

JO - РОССИЙСКИЙ ФИЗИОЛОГИЧЕСКИЙ ЖУРНАЛ ИМ. И.М. СЕЧЕНОВА

JF - РОССИЙСКИЙ ФИЗИОЛОГИЧЕСКИЙ ЖУРНАЛ ИМ. И.М. СЕЧЕНОВА

SN - 0869-8139

IS - 3

ER -

ID: 99384706