TY - JOUR

T1 - СВЯЗЬ ПСИХОСОЦИАЛЬНОГО БЛАГОПОЛУЧИЯ БОЛЬНЫХ ШИЗОФРЕНИЕЙ С КЛИНИЧЕСКИМИ, СОЦИАЛЬНО-ДЕМОГРАФИЧЕСКИМИ И НЕЙРОКОГНИТИВНЫМИ ХАРАКТЕРИСТИКАМИ

AU - Софронов, Александр Генрихович

AU - Добровольская, Алла Евгеньевна

AU - Трусова, Анна Владимировна

AU - Гетманенко, Яна Александровна

AU - Гвоздецкий, Антон Николаевич

N1 - Софронов А.Г., Добровольская А.Е., Трусова А.В., Гетманенко Я.А., Гвоздецкий А.Н. Связь психосоциального благополучия больных шизофренией с клиническими, социально-демографическими и нейрокогнитивными характеристиками // Журнал неврологии и психиатрии им. C.C. Корсакова. – 2020. – Т. 120. – № 6-2. – С. 105-112. DOI: 10.17116/jnevro2020120062105

PY - 2020

Y1 - 2020

N2 - Objective. To explore the relationship between the indicators of quality of life (QOL) and social functioning (SF) of patients with schizophrenia with clinical and socio-demographic characteristics, indicators of cognitive functions and the severity of disease symptoms, using mathematical modeling methods. Material and methods. The sample consisted of 300 patients with paranoid schizophrenia (aged 18-50 years, disease duration at least 5 years; total PANSS score <120). Clinical-psychopathological, psychometric and mathematical methods were used. A mathematical model based on the construct developed by the authors called the «Disease Burden Factor» (Factor «B») was utilized. Results and Conclusion. Statistically significant correlations of factor “B” with age, the time of disease onset, seeking psychiatric help and diagnosis, the length of hospital admissions in the past 12 months and PANSS and BACS scores were established. Factor «B» clusters of «prosperous» and «dysfunctional» patients, significantly differing in the frequency of exacerbations of the disease, its total duration, and indicators of QOL-SM, PSP, PANSS, BACS, were distinguished. The conclusion about the reliability and sensitivity of a new toolbox - Factor «B» for exploring the mutual influence of heterogeneous factors affecting the trajectory of patients with schizophrenia was made.

AB - Objective. To explore the relationship between the indicators of quality of life (QOL) and social functioning (SF) of patients with schizophrenia with clinical and socio-demographic characteristics, indicators of cognitive functions and the severity of disease symptoms, using mathematical modeling methods. Material and methods. The sample consisted of 300 patients with paranoid schizophrenia (aged 18-50 years, disease duration at least 5 years; total PANSS score <120). Clinical-psychopathological, psychometric and mathematical methods were used. A mathematical model based on the construct developed by the authors called the «Disease Burden Factor» (Factor «B») was utilized. Results and Conclusion. Statistically significant correlations of factor “B” with age, the time of disease onset, seeking psychiatric help and diagnosis, the length of hospital admissions in the past 12 months and PANSS and BACS scores were established. Factor «B» clusters of «prosperous» and «dysfunctional» patients, significantly differing in the frequency of exacerbations of the disease, its total duration, and indicators of QOL-SM, PSP, PANSS, BACS, were distinguished. The conclusion about the reliability and sensitivity of a new toolbox - Factor «B» for exploring the mutual influence of heterogeneous factors affecting the trajectory of patients with schizophrenia was made.

KW - шизофрения

KW - ПАТОПЛАСТИЧЕСКИЕ ФАКТОРЫ

KW - СОЦИАЛЬНОЕ ФУНКЦИОНИРОВАНИЕ

KW - КАЧЕСТВО ЖИЗНИ

KW - НЕЙРОКОГНИТИВНЫЙ ДЕФИЦИТ

KW - SCHIZOPHRENIA

KW - PATHOPLASTIC FACTORS

KW - social functioning

KW - quality of life

KW - NEUROCOGNITIVE DEFICIT

KW - Pathoplastic factors

KW - Schizophrenia

KW - Social functioning

KW - Neurocognitive deficit

KW - Quality of life

UR - https://elibrary.ru/item.asp?id=43179966

UR - http://www.scopus.com/inward/record.url?scp=85089126612&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/5ec595e1-a909-3dbd-8bd9-b6943aa054e4/

U2 - 10.17116/jnevro2020120062105

DO - 10.17116/jnevro2020120062105

M3 - статья

VL - 120

SP - 105

EP - 112

JO - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА

JF - ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. C.C. КОРСАКОВА

SN - 1997-7298

IS - special issue 6

ER -