НЕЙРОТРОПНАЯ АКТИВНОСТЬ НОВОГО ПРОИЗВОДНОГО АМИНОЭТАНОЛА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОЙ ИШЕМИИ ГОЛОВНОГО МОЗГА

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НЕЙРОТРОПНАЯ АКТИВНОСТЬ НОВОГО ПРОИЗВОДНОГО АМИНОЭТАНОЛА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОЙ ИШЕМИИ ГОЛОВНОГО МОЗГА. / Titovich, I. A.; Sysoev, Y. I.; Bolotova, V. C.; Okovityi, Arid S.V.

в: Eksperimental'naya i Klinicheskaya Farmakologiya, Том 80, № 5, 2017, стр. 3-6.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{0a652833243f417ba4f8401025929bae,

title = "НЕЙРОТРОПНАЯ АКТИВНОСТЬ НОВОГО ПРОИЗВОДНОГО АМИНОЭТАНОЛА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОЙ ИШЕМИИ ГОЛОВНОГО МОЗГА",

abstract = "The neurotropic activity of a new aminoethanol derivative with butanediol and trans-ethylene-l,2-dicarboxylic acid, (2E)-4-[2-(diethylamino)ethoxyl-4-oxo- but-2-ene butanedtoate (2 : 1), has been studied during course peroral introduction (10 mg/kg) in rats with experimental cerebral ischemia caused by bilateral permanent occlusion of both common carotid arteries. The animals were tested with respect to orientation-exploratory behavior and coordination of movements in rotarod and open-field tests. The new agent activity was comparable with that of reference drugs citicoline (500 mg/kg) and cytoflavin (170 mg/kg).",

keywords = "Citicoline, Citoflavin, Deanol aceglumate, Fdes, Ischemic stroke, Open field test, Rats, Rotarod test",

author = "Titovich, {I. A.} and Sysoev, {Y. I.} and Bolotova, {V. C.} and Okovityi, {Arid S.V.}",

year = "2017",

doi = "10.30906/0869-2092-2017-80-5-3-6",

language = "русский",

volume = "80",

pages = "3--6",

journal = "ЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ",

issn = "0869-2092",

publisher = "Медицина",

number = "5",

}

RIS

TY - JOUR

T1 - НЕЙРОТРОПНАЯ АКТИВНОСТЬ НОВОГО ПРОИЗВОДНОГО АМИНОЭТАНОЛА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОЙ ИШЕМИИ ГОЛОВНОГО МОЗГА

AU - Titovich, I. A.

AU - Sysoev, Y. I.

AU - Bolotova, V. C.

AU - Okovityi, Arid S.V.

PY - 2017

Y1 - 2017

N2 - The neurotropic activity of a new aminoethanol derivative with butanediol and trans-ethylene-l,2-dicarboxylic acid, (2E)-4-[2-(diethylamino)ethoxyl-4-oxo- but-2-ene butanedtoate (2 : 1), has been studied during course peroral introduction (10 mg/kg) in rats with experimental cerebral ischemia caused by bilateral permanent occlusion of both common carotid arteries. The animals were tested with respect to orientation-exploratory behavior and coordination of movements in rotarod and open-field tests. The new agent activity was comparable with that of reference drugs citicoline (500 mg/kg) and cytoflavin (170 mg/kg).

AB - The neurotropic activity of a new aminoethanol derivative with butanediol and trans-ethylene-l,2-dicarboxylic acid, (2E)-4-[2-(diethylamino)ethoxyl-4-oxo- but-2-ene butanedtoate (2 : 1), has been studied during course peroral introduction (10 mg/kg) in rats with experimental cerebral ischemia caused by bilateral permanent occlusion of both common carotid arteries. The animals were tested with respect to orientation-exploratory behavior and coordination of movements in rotarod and open-field tests. The new agent activity was comparable with that of reference drugs citicoline (500 mg/kg) and cytoflavin (170 mg/kg).

KW - Citicoline

KW - Citoflavin

KW - Deanol aceglumate

KW - Fdes

KW - Ischemic stroke

KW - Open field test

KW - Rats

KW - Rotarod test

UR - http://www.scopus.com/inward/record.url?scp=85030706816&partnerID=8YFLogxK

U2 - 10.30906/0869-2092-2017-80-5-3-6

DO - 10.30906/0869-2092-2017-80-5-3-6

M3 - статья

AN - SCOPUS:85030706816

VL - 80

SP - 3

EP - 6

JO - ЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ

JF - ЭКСПЕРИМЕНТАЛЬНАЯ И КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ

SN - 0869-2092

IS - 5

ER -

ID: 87474223